PEDS Chapter 35: Key Pediatric Nursing Interventions Flashcards
Eight Rights of Pediatric Medication
Right medication Right patient Right time Right route of administration Right dose Right documentation Right to be educated Right to refuse
Pharmacodynamics
Behavior of medication at the cellular level
Affected by the physiologic immaturity of some body systems in a child
Pharmacokinetics
Movement of drugs throughout the body via absorption, distribution, metabolism, and excretion
Affected by the child’s age, weight, body surface area, and body composition
Oral medications
slower gastric emptying, increased intestinal motility, a proportionately larger small intestine surface area, higher gastric pH, and decreased lipase and amylase secretion compared with adults
Intramuscular absorption
amount of muscle mass, muscle tone and perfusion, and vasomotor instability
Subcutaneous absorption
decreased perfusion
Topical absorption of medications
increased due to greater body surface area and greater permeability of infant’s skin
Factors Affecting Distribution of Medication in Children
Higher percentage of body water than adults
More rapid extracellular fluid exchange
Decreased body fat
Liver immaturity, altering first-pass elimination
Decreased amounts of plasma proteins available for drug binding
Immature blood–brain barrier, especially neonates, allowing permeation by certain medications
The nurse is administering amoxicillin orally to an infant with a bacterial infection. Which of the following developmental factors might affect the absorption of this medication?
a. slower gastric emptying b. vasomotor instability c. decreased perfusion d. greater body surface area
a. slower gastric emptying. Slower gastric emptying might affect the absorption of amoxicillin.
Rationale: Slower gastric emptying might affect the absorption of amoxicillin since it is being given orally. Vasomotor instability might affect intramuscular absorption of medication. Decreased perfusion alters subcutaneous administration of medication and may decrease absorption. Greater body surface area may increase the effect of topical administration of medication.
Factors Affecting Metabolism of Medications in Children
Differences in hepatic enzyme production
Increased metabolic rate
Biotransformation
Is affected by the same variations affecting distribution in children
Developmentally Appropriate Explanations for Medications for Children
Why the drug is needed
What the child will experience
What is expected of the child
How the parents can participate and support their child
Determining Children’s Doses by Body Weight
Weigh the child.
If the child’s weight is in pounds, convert it to kilograms (divide the child’s weight in pounds by 2.2).
Check a drug reference for the safe dose range (e.g., 10 to 20 mg/kg of body weight).
Calculate the low safe dose.
Calculate the high safe dose.
Determine if the dose ordered is within this range.
The safe dose of a medication is 10 to 20 mg/kg. What would the nurse calculate as the low safe dose for a child who weighs 40 kg?
a. 100 mg b. 200 mg c. 300 mg d. 400 mg
d. 400 mg. 400 mg is the low safe dose for a child who weighs 40 kg if the safe dose of a medication is 10 to 20 mg/kg.
Rationale: to calculate the low safe dose use the following proportion:
10 mg/1 kg = x mg/40 kg
Solve for x by cross-multiplying
1 × x = 10 × 40
x = 400 mg
Guidelines to Determine BSA
Measure the child’s height.
Determine the child’s weight.
Using the nomogram, draw a line to connect the height measurement in the left column and the weight measurement in the right column.
Determine the point where this line intersects the line in the surface area column. This is the BSA, expressed in meters squared (m2).
Forms of Oral Medications
- Liquids
- Elixirs
- Syrups
- Suspensions
- Powders
- Tablets
- Capsules