Pediatrics Flashcards
ALL background and incidence -5
Most common pediatric cancer by far
2400 new cases/year in US
80% ALL and 20% AML
Peak incidence for ALL is 2-3 years of age
Cause is unknown
ALL signs and symptoms -8
common misdiagnosis is rheumatoid arthritis
WBC is normal or low in 59% of kids
Normochromic, normocytic anemia
Thrombocytopenia
Fever
Bleeding
Bone pain (limping, want to be carried)
Lymphadenopathy
Hepatosplenomegaly
ALL dx -3
Bone marrow aspirate and biopsy
If at least 25% of lymphoid cells in BM are blasts, the patient has ALL
MRD = MINIMAL RESIDUAL DISEASE is tested during induction
ALL tx - TLS -5
First, deal with tumor lysis issues
Hydrate (maintenance fluids = 1500ml/m2/day), give 1.5-2 times this rate
Alkalinization has fallen out of favor. Thought it kept uric acid in solution, but not shown to be helpful. however some places use it.
Allopurinol
Rasburicase if uric acid is >10mg/dl or Creatinine is elevated or WBC is greater than 100,000/mm3
ALL tx - TLS - At a glance method for evaluating creatinine: -3
Creatinine is normally 0.2mg/dl up to 2 years of age
Then you add 0.1mg/dl per year until they reach 8 years of age,
Then their creatinine values are the same as adults
ALL - Induction - key concepts -3
DOES RISK STRATIFICATION MATTER?
Lasts 4 weeks
Standard risk: 3 drugs (besides IT chemo)
High risk: 4 drugs (besides IT chemo)
ALL - Induction - high risk definition -4
kids less than 1 year of age or greater than 9 years of age,
presenting WBC > 50,000,
T-cell ALL,
certain translocations
ALL - Induction - 3 drug regimen -6
DEX INC RISK OF AVASCULAR NECROSIS IF PT >9YR
DOSING DURING INDUCTION IS NOT BASED ON BLOOD COUNTS
Prednisone 40mg/m2/day or dexamethasone 6mg/m2/day for 28 days
ALL - IT methotrexate -2
Dose is based on age with a max of 15mg for kids greater than or equal to 9 years of age
Example is MTX
1-1.99 years get 8mg
2-2.99 years get 10mg
3-8.99 years get 12mg
greater than or equal to 9 years get 15mg
ALL - Induction - 4 drug regimen -2
Use the 3 drug regimen, plus daunorubicin 25mg/m2 IV on days 2, 8 and +/- 15
If daunorubicin is used, then the steroid must be prednisone because the combo of daunorubicin and dexamethasone poses a greater risk of fungal infections
ALL - monitoring response -3
Do BM aspiration at day 7 or 14 and at day 28
ALL - Post-Remission Therapy: aka Consolidation, early or delayed intensification - concepts -5
IS OPTIMAL REGIMEN KNOWN?
WHAT IS INTENSITY AND DURATION OF TX BASED ON?
Begins if the patient is in remission after induction
ALL - Post-Remission Therapy: aka Consolidation, early or delayed intensification - regimens -6
PROBABLY NOT ON TEST - NO SOC
Methotrexate 1gm/m2 IV q3 weeks x 6 doses
Escalating dose methotrexate plus Pegaspargase
Cyclophosphamide1gm/m2 followed by cytarabine 75mg/m2 SQ or IV x 10 days with thioguanine x 14 days
Vincristine/pred pulses, doxorubicin, various doses of asparaginase
High risk kids get more aggressive treatment for a longer duration, regimens include high dose MTX 5gm/m2 and high dose asparaginase (25,000 units/m2) IM
Longer duration for boys due to risk of testicular relapse
ALL - Post-Remission Therapy: mainenance concepts -3
Without maintenance therapy, most kids with ALL will relapse - compliance also effects relapse
Can still have undetectable disease after induction and consolidation (MRD)
Trying to knock off cells coming out of G0 phase over a couple of years
ALL - Post-Remission Therapy: mainenance regimen -5
WHAT IS USED FOR DOSE ADJUSTMENT?
ANC’s are best to see if pt taking drug. used to dose adjust.
Methotrexate 20mg/m2 usually by mouth once a week x 1.5-2 years
Mercaptopurine 50-75mg/m2 daily x 1.5-2 years
Doses adjusted to keep ANC between 500-1500/mm3
Periodic IT methotrexate (example = every 16 weeks)
Periodic Vincristine x1 plus 7 day pred or dex pulses (VP pulse)
Relapsed ALL -2
WHERE DOES DZ RELAPSE?
CNS relapse – treat with cranial radiation and re-induction/re-consolidation therapy and then maintenance
BM relapse- if they relapse on therapy or within 1 year post chemo completion, BMT is a better option than more chemo. Chance of 2nd remission is good, but long term survival is often less than 50%
ALL -Radiation concepts -2
WHAT IS MAIN USE?
ADR?
Cranial XRT used in kids with T-cell ALL
Main use is for CNS relapse
Causes growth deficiency and impaired intellectual development
ALL prognosis -7
WHAT AGE IS BEST?
WHAT WBC IS BEST?
85-90% long term survival
Age 1-9 years is best
Initial WBC < 50K is favorable
MRD (if detected, is bad) is used to tailor post-remission therapy
favorable: hyperdiploid; trisomy 4, 10, or 17 have lower risk of relapse, TEL/AML1 t(12;21)
Unfavorable: t(9;22) = Philadelphia chromosome, MLL rearrangements: t(4;11), t(11;19) and t(1;11)
Early response; bone marrow remission on day 7 or 14 is favorable
AML regimen -3
Cytarabine 3000mg/m2 IV over 3 hours every 12 hours for 6 doses alternating with the next course at 100mg/m2/day continuous infusion for 7 days
Daunorubicin 45-60mg/m2 IV daily for 2-3 days per course
Courses repeated for 4-6 months
AML concepts -6
WHERE IS MOST COMMON RELAPSE?
DO YOU USE MAINTENANCE?
chemo is of shorter duration overall vs ALL, but it is much more toxic
AML: post induction tx -3
WHAT IS PREFERRED?
WHAT IS CONSOLIDATION VS INTENSIFICATION?
If the patient has a living related donor who matches, they go to BMT once in complete remission
Consolidation: if different agents (vs induction agents) are used
Intensification: if the same agents are used but at higher doses
AML prognosis (6pts)
50% long term survival
60% OS with HSCT from living related donor
Some subtypes have more favorable prognosis
Poor prognosis with monosomy 7, -5/5q-, or FLT3/ITD allelic ratio
BM blasts at day 15 and MRD of 1% or more after 1st induction are bad prognostic indicators
Age less than 1 and WBC > 20,000/mm3 have worse prognosis (3-10yo have best prognosis)
Late effects with ALL and AML (4pts)
anthracycline cardiotoxicity
secondary AML (for ALL patients who got epipodopylotoxins - LESS BECAUSE NOT BEING USED MUCH ANYMORE)
decreased bone mineral density (steroids)
leukoencephalopathy (high dose methotrexate) - lifetime learning problems
XRT neurocog problems LESS as this tx is avoided as much as possible, especially if <5yo
Pediatric CNS tumors (3 main types)
Medulloblastoma
Astrocytoma
Brain stem gliomas
Pediatric CNS tumors- Medulloblastoma -5
A primitive neuroectodermal tumor (PNET)
Median age at diagnosis = 5-6 years
Arises in cerebellum
25-45% have leptomeningeal mets at diagnosis
Rapidly growing, so short duration of symptoms - BECAUSE OF THIS AMENABLE TO CHEMO
Pediatric CNS tumors- Medulloblastoma - signs and sx -6
Early symptoms:
signs and symptoms of increased ICP, headache, emesis, lethargy, hydrocephalus
Late symptoms : ataxia, diplopia, weakness, papilledema, strabismus
Pediatric CNS tumors- Medulloblastoma - staging : favorable vs high risk -4
WHAT DOES RESIDUAL DZ MEAN TO RISK?
DOES AGE MATTER?
Favorable disease:
1. children older than 3 years of age,
- localized disease that has complete or near total resection
High risk:
1. invasive disease that limits total resection (greater than 1.5cm2 residual disease)
- overt metastatic disease (subarachnoid seeding)
Pediatric CNS tumors- Medulloblastoma - staging -Chang Classification (prognostic value) -5
M IS PROGNOSTIC NOT T
M0 = No gross subarachnoid or heme mets
M1 Microscopic tumor cells in CSF
M2 Gross nodular seeding in cerebellum, cerebral subarachnoid space, or in third or fourth ventricles
M3 Gross nodular seeding in spinal subarachnoid space
M4 Extraneuraxial metastasis
Pediatric CNS tumors- Medulloblastoma - treatment - surgery -3
TX IS SURGERY+XRT+CHEMO
Surgery is KEY! Need complete or near complete resection.
Can do post-op MRI to detect residual disease and operate a second time to improve resection.
Bone marrow aspirate and biopsy (5% have systemic mets)
Pediatric CNS tumors- Medulloblastoma - treatment - XRT -4
wonderful addition, but only if you are at least 3 years of age, IDEALLY OVER 5 YO
Attempting to use chemo to decrease dose of XRT or avoid it altogether.
inability to give XRT to younger kids hurts their chances of survival
Some low risk patients can be cured with post-op radiation
Pediatric CNS tumors- Medulloblastoma - treatment - chemo -5
IS THERE A SOC?
NO SOC
Cisplatin, vincristine, prednisone, cyclophosphamide, lomustine and topotecan have been used post-op.
Chemo used to avoid XRT in very young (<3)
Chemo can be used with XRT to decrease the dose of XRT used in low risk patients
Unclear if chemo improves survival in low risk patients
Pediatric CNS tumors- Medulloblastoma - treatment - chemo examples -2
CVP
lomustine (CCNU) 100mg/m2 po x 1
vincristine 1.5mg/m2 IV weekly x 3
prednisone 40mg/m2 po x 14 days
Cisplatin 90mg/m2 IV x 1
Lomustine 100mg/m2 PO x 1
Vincristine 1.5mg/m2 weekly x 3
Most important prognostic factors for medulloblastoma -3
metastatic stage M
adjuvant treatment
residual tumor
Pediatric CNS tumors- Medulloblastoma - prognosis -7
60-80% survival rate based on how aggressive surgery was as well as chemo, XRT
Poor risk: less than 3 years of age, subarachnoid seeding, greater than 1.5cm2 tumor remaining post-op, histology, diploid DNA content, C-myc amplification, deletion of 17p
Pediatric CNS tumors- Astrocytomas - background
NOT COVERED IN VIDEO
#Most are slow growing (low grade): I and II #About 20% are malignant (anaplastic astrocytoma or glioblastoma) # 2 histologic types: juvenile pilocytic astrocytomas and diffuse astrocytomas
Pediatric CNS tumors- Astrocytomas - signs and sx
associated with increased ICP, seizures, visual disturbances, can be similar to medulloblastoma depending on their location
Pediatric CNS tumors- Astrocytomas - treatment - surgery
#curative intent for Cerebellar astrocytomas # malignant astrocytomas and glioblastoma, the goal is maximal resection
Pediatric CNS tumors- Astrocytomas - tx - XRT
# avoid in kids <3-5 if possible #prolong time to tumor progression if there was an incomplete resection of malignant astrocytoma or glioblastoma
Pediatric CNS tumors- Astrocytomas - tx - chemo
#multiagent, dose-intense #cyclophosphamide, cisplatin, carboplatin, etoposide, vincristine, carmustine (carboplatin is in most regimens since it is among the most active) #Chemo used where radiation deferred or failed or where surgery not a good option
Pediatric CNS tumors- Astrocytomas - tx - chemo example regimen
Carboplatin 175mg/m2 IV weekly x 4
Vincristine 1.5mg/m2 (0.05mg/kg if less than 12kg) IV weekly
Pediatric CNS tumors- Astrocytomas - prognosis
#Worst prognosis: malignant astrocytoma and glioblastoma #Extent of resection important for cerebellar gliomas #The older the patient, the worse the prognosis
Pediatric CNS tumors- Brain stem gliomas - background
NOT COVERED IN VIDEO
#Most frequently occur between 5-10 yo #Usually in pons, can be in medulla and midbrain
Pediatric CNS tumors- Brain stem gliomas - signs and sx
rarely cause increased ICP until late in course
Extra ocular muscle paresis and diplopia, facial weakness, cranial nerve dysfunction, personality changes
Spastic gait, hemiparesis
Pediatric CNS tumors- Brain stem gliomas - staging and prognosis
#diffuse infiltrative (usually in pons, poor prognosis, median OS <1yr) #focal (in medulla or midbrain) - good prognosis if can be removed surgically +/- radiation – survival 50-100%
Pediatric CNS tumors- Brain stem gliomas - tx - surgery
remove as much as possible while preserving neurologic function