Basal cell carcinoma AND squamous cell cancer Flashcards

1
Q

incidence and natural hx -4

A

BCC most common human cancer

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2
Q

BCC etiology -3

A

basal cell layer,

mets rare,

extensive local damage if untreated

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3
Q

SCC etiology -4

A

rapid growth,

local invansion,

mets potential,

perineural involvement associated with increased risk of recurrence post tx and inc risk of mets

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4
Q

risk factors -9

A
UV light, 
age, 
actinic keratoses,
 ionizing radiation, 
chronic immunosuppression, 
viruses, 
chronic arsenic exposure, 
chronic skin inflammation, 
genetic conditions (xeroderma pigmentosum, epidermolysis bullosa, albinism, epidermodysplasia verruciformis)
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5
Q

risk factors for recurrence -7

A

increased size,

poorly differentiated borders,

recurrent dz,

site of prior RT,

immunosuppression,

aggressive growth pattern,

perineural involvement

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6
Q

prevention -3

A

minimize UV,

sunscreen,

treat actinic keratosis (premalignant SCC) with retanoids

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7
Q

signs and sx -4

A

nodularity,

erythema,

scaly plaque,

necrosis

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8
Q

primary tx concepts -7

A

goal: cure of tumor AND maximal preservation of function

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9
Q

vismodegib indication

A

metastatic or locally advanced BCC that has recurred following surgery or who are not candidates for surgery or XRT

CR 21-22%

median response duration: 7.6 mo

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10
Q

vismodegib ADR -12

A
muscle spasms, 
alopecia, 
dysgeusia, ageusia
wt loss, 
fatigue, 
N, D, V
dec appetite, 
constipation, 
arthralgias
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11
Q

follow up -3

A

close follow-up extremely important with pt counseling

BCC - q6mo x5yr (36% develop another primary BCC within 5yrs)

SCC - q3mo x5yr, then q6mo indefinitely

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12
Q

prognosis -2

A

2000 deaths out of 1-2 million new dx

rare met dz <50% 5yr OS

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