Hodgkins Lymphoma Flashcards

1
Q

HL pathophysiology

A

Reed-Sternberg cell (CD15+ and CD30+) - histology 75% nodular sclerosing

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2
Q

HL negative prognositc factors

A

albumin 45yo, WBC >15k, lymphopenia <8% of WBC

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3
Q

HL by prognostic factors and OS

A

0-2: 5yr PFS 74%, 5yr OS 86%

>or equal to 3: 5yr PFS 55%, 5yr OS 70%

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4
Q

HL localized stage I, nonbulky II- treatment

A

less is more to prevent 2nd cancers: ABVD x2 + 20Gy XRT: 5yr OS 96.6% : could give just ABVD if pt can’t tolerate XRT

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5
Q

HL stage bulky II/III/IV - treatment

A

ABVD x6-8 CR 82%, 5yr OS 73% vs MOPP CR 67%, 5yr OS 66% (also better OS than Stanford V and MOPP/ABVD combo)

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6
Q

HL treatment - MOPP

A

more male sterility, more secondary malignancy (10%)

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7
Q

HL stage bulky II/III/IV - treatment – BEACOPP vs ABVD (std of care)

A

similar OS; 7 yr OS 89 vs 84% (p=0.39), Beacopp more toxic (higher heme 81 vs 43% and non-hem 19 vs 7%)

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8
Q

BEACOPP escalated vs std dosing

A

no difference in OS outcomes

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9
Q

HL incidence of long term TOX: ABVD vs MOPP/ABVD

A

cardiac (acute MI, angina, CHF) 50, infertility (female) 0 vs 20-80%, AML <1% vs 3-5%

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10
Q

HL relapsed - 2nd line

A

autoSCT 3yr EFS 53% vs std dose chemo 10%; no need for chemosensitivity testing prior to autoSCT

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11
Q

HL relapsed - 3rd line, post autoSCT

A

brentuximab CR 34%, RR 75%, duration 20.5mo

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12
Q

brentuximab vedotin TOX

A

myelosuppression, neuropathy, infusion events, pulmonary fibrosis, PML

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13
Q

HL relapsed - 3rd line, post alloSCT

A

brentuximab CR 38%, RR 50%, median PFS 7.8mo

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