PD- COMTI DI

Question 1

COMTis used in PD

Answer 1

Entacapone, tolcapone

Question 2

Entacapone and tolcapone MoA

Answer 2

Reversible, selective inhibitor of COMT and prevents the breakdown of L-dopa

Question 3

Do COMTis have effects without L-dopa

Answer 3

Nope

Question 4

Where does entacapone act?

Answer 4

Peripherally

Question 5

Entacapone ADEs

Answer 5

Similar side effects to L-dopa (N/V, hallucinations/psychiatric ADEs, orthostatic hypotension, etc.)

May produce orange/brown urine

Question 6

Entacapone and tolcapone DDIs

Answer 6

Drugs metabolized by COMT, nonselective MAOIs

Question 7

Tolcapone CI

Answer 7

hepatic disease

Question 8

Where does tolcapone act?

Answer 8

Centrally and peripherally

Question 9

Tolcapone ADEs

Answer 9

Similar side effects to L-dopa, also has increased LFTs and delayed onset diarrhea

Question 10

Why is tolcapone rarely used today?

Answer 10

Risk of hepatocellular injury

Question 11

Stalevo is a combination of what drugs?

Answer 11

Carbidopa, levodopa, and entacopone

Ratio is 1 carbidopa: 4 L-dopa : 200mg entacapone