PD- Amantadine DI

Question 1

MoA of amantadine

Answer 1

We THINK it increases DA release and inhibits reuptake –> decreased rigidity, tremor, bradykinesia, L-dopa induced dyskinesia

Question 2

Precautions of amantadine

Answer 2

CHF, orthostatic hypotension, peripheral edema

Question 3

Does amantadine need renal adjustment?

Answer 3

Yes, it’s 90% eliminated by the kidneys

Question 4

Amantadine ADEs

Answer 4

orthostatic hypotension/falls, hallucinations, sedation, anticholinergic ADEs (sialorrhea, lacrimation, urination, defecation, GI effects, emesis), livedo reticularis (mottling of the skin with LE edema), NMS with abrupt D/C

Question 5

Amantadine DDIs

Answer 5

Flumist, quinine/quinidine, HCTZ, triamterene