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Year 1 (PCS & Cases 1-6) > PCS 1 > Flashcards

PCS 1 Flashcards

1
Q

What is an amphiobolic reaction?

A

A catabolic and anabolic reaction together e.g. Krebs

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2
Q

What is mean by the term ‘Accommodation’?

A

Slow and prolonged depolarization due to inactive sodium channels.

Sodium cannot be transported into the cell therefore depolarization occurs slowly.

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3
Q

What is the function of a tight junction? What are the proteins that make them up called?

A

They link epithelial cells together. Claudins are transmembrane proteins present in tight junctions .

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4
Q

What is the main regulatory point in glycolysis? What steps does it catalyse?

A

PFK.

Fructose-6-Phosphate –> Fructose-1,6-Bisphosphate

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5
Q

What are the three most commonly fractured carpal bones?

A
  1. Scaphoid 2. Triquetrum 3. Lunate
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6
Q

What is the function of the Biceps Brachii?

A

FLEXES and SUPINATES the forearm at the elbow joint.

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7
Q

In which muscle type(s) are the contractile filaments organized into sarcomeres?

A

Cardiac and Skeletal muscles.

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8
Q

Which cell type gives rise to osteoblasts?

A

Osteoprogenitor cell

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9
Q

What is the definition of a motor unit?

A

One lower motor neurone and all the skeletal muscle fibers that it innervates.

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10
Q

What makes up ground substance?

A

GAGs and Proteoglycans.

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11
Q

In which muscle type(s) are satellite cells present?

A

Skeletal. Satellite cells are stem cells.

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12
Q

Go through the steps of muscle contraction with actin and myosin including the power stroke.

A
  1. ATP bind to myosin.
  2. Binding of ATP to myosin causes the myosin to dissociate from actin.
  3. ATP hydrolysis into ADP and Pi. This causes myosin to change the angle of its head.
  4. With ADP and Pi still present, myosin binds to actin at a new angle.
  5. When Pi leaves, myosin pulls against actin, causing the power stroke (contraction!)
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13
Q

What is calculated using the Nernst Equation?

A

Equilibrium Potenital

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14
Q

What is the resisting membrane potential for sodium and potassium?

A

Sodium +60mV

Potassium -90mV

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15
Q

Name the FOUR major classes of simple epithelia.

A

Squamous, cuboidal, columnar, pseudostratified

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16
Q

What enzyme catalyses the link reaction? Steps involved?

A

Pyruvate dehydrogenase.

Pyruvate –> Acetyl CoA.

Irreversible reaction.

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17
Q

What is the function of the carnitine shuttle?

A

Transporting fatty acids from the intermembranous space of the mitochondria to the mitochondrial matrix.

Without this shuttle, the fatty acids would not be able to be transported into the matrix, meaning fatty acids would not be available to be metabolised, making it the rate limiting factor.

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18
Q

What reaction does Hexokinase catalyse?

A

Glucose –> Glucose-6-Phosphate (via the transfer of a phosphate molecule from ATP to glucose)

1st step in glycolysis

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19
Q

What are the three main controls in glycolysis?

A

Phosphofructokinase

Hexokinase

Pyruvate Kinase

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20
Q

What determines the contraction speed of skeletal muscle fibers?

A

ATPase activity of myosin

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21
Q

What is the action of Myosin Light chain kinase?

A

Phosphorylates myosin, allowing it to bind to actin for contraction to occur.

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22
Q

What is the action of Myosin Light chain phosphotase?

A

Dephosphorylates myosin light chain / detatches cross bridges. Inhibits muscle contraction.

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23
Q

Name the epithelium lining the tongue.

A

Non-keratinised stratified squamous epithelium.

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24
Q

What proteins form gap junctions?

A

Connexons. They require 6 connexins to form one connexon.

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25
What proteins are involved in Adhering Junctions?
Cadherin molecules bound to actin.
26
What proteins are involved in Gap Junctions?
Connexons
27
What proteins are involved in Hemidesmosomes?
Integrins
28
What proteins are involved in Desmosome junctions?
Cadherin to Keratin filaments
29
In glycolysis, what does Phosphoglucose Isomerase catalyse?
The second step! Glucose 6-phosphate - Fructose 6-phosphate
30
What are the products in TCA cycle?
3 NADH 1 FADH 2 Co2 1 GTP
31
What is the function of complex 1-4 in the ETC?
Complex 1 -\> **_NADH- CoQ reductase_** (transfers electrons from NADH to CoQH2) Complex 2 --\> **_Succinate CoQ reductase_** (uses FADH2 and is part of kreb cycle too) Complex 3 --\> **_CoQ Cytochrom c reductase_** (transfers electrons from COQH2 to Cyt c) Complex 4 --\> **_Cytochrome C Oxidase_** (final complex in ETC)
32
What are Islets of Langerhans?
Endocrine tissue found in the pancreas which releases glucagon and insulin.
33
Which complex in the electron transport chain does carbon monoxide inhibit?
Complex IV
34
What is the problem in Mcardle’s disease?
The inability to produce glycogen phosphorylase. (required to break down glycogen to glucose)
35
# Fill in the table for Insulin. a) origin b) metabolic effects c) effect on blood glucose levels
36
# Fill in the table for Glucagon. a) origin b) metabolic effects c) effect on blood glucose levels
37
# Fill in the table for Adrenaline. a) origin b) metabolic effects c) effect on blood glucose levels
38
# Fill in the table for Cortisol. a) origin b) metabolic effects c) effect on blood glucose levels
39
# Fill in the table for Growth Hormone a) origin b) metabolic effects c) effect on blood glucose levels
40
If you ran a 100m sprint, what would be your main energy source?
A 100m sprint requires a *_short_* burst of energy. In most cases, ***pre-synthesised ATP, creatine phosphate and anaerobic glycolysis*** are the main processes that provide ATP to make you sprint. Oxidative phosphorylation would be too slow to activate.
41
What would be he main energy source for running between 100m - 1km?
***Oxidative Phosphorylation*** is usually sufficient enough to provide energy to one going from over 100m to 1km. ***Glycogen*** may begin to be used towards the end of this time but it would not be the 'main' energy resource.
42
What energy sources would be used when running a half marathon? Would it be the same source throughout or would it change?
***Oxidative phosphorylation*** is used for the *first* part of the half-marathon and may be used throughout the race. After about 1km, your body will begin to use ***glycogen*** reserves and ***Beta-oxidation of fatty acids*** to primarily provide your ATP needs over a long period of time.
43
Is the brain insulin _sensitive_ or _resistant_?
It is considered an ***_insulin resistant organ_*** The main places where insulin acts are hepatocytes, adipocytes and myocytes.
44
What is the main energy source for a red blood cell?
RBCs have *_no nucleus_* or mitochondria. _oxidative phosphorylation_ and _beta oxidation_ ***cannot take place*** so ... ***_GLUCOSE_*** can be the only molecule used by the cell to generate ATP.
45
What does a 2% NaCl solution mean?
0.02 x 100 = 2g/100ml
46
What does 0.9% NaCl solution mean?
0.9g/100ml
47
Convert the units of 2% NaCl solution into mg/ml units
2% = 2g/100ml 2000mg/100ml i.e. 20mg/ml
48
What is the liver isoform of hexokinase called?
***Glucokinase*** Requires a much higher glucose concentration for maximal activity. It has a high Km - requires more substrate to work. Most active after the consumption of a carbohydrate rich meal.
49
How does DNP (2,4-dintirophenol) disrupt ATP synthesis?
It ***disrupts the proton gradient*** in the electron transport chain. DNP is a ***hydrophobic*** molecule, so can freely diffuse across the inner mitochondrial membrane. It can ***carry protons*** across the inner mitochondrial membrane, which is normally impermeable to them. This means that they don't go down the usual route, through ATP synthase. This means that normal ***ATP synthesis stops***. It is said to be an *_'uncoupler' of oxidative phosphorylation._*
50
How many molecules of NADH are produced for each pyruvate --\> acetyl CoA?
1
51
Which electron carrier is produced by Vitamin B3?
NADH
52
What 2 components make up the nicotinamide ring of NAD+?
Niacin (vitamin B3) Tryptophan
53
What occurs when NAD+ accepts electrons?
A hydride ion covalently binds to it, reducing NAD+ to NADH, and oxidizing the substrate.
54
What occurs when FAD accepts electrons?
It gets reduced as it accepts 2 hydride ions, and the substrate is oxidized.
55
What do the reduced cofactors FADH2 and NADH do with their electrons?
Transfer them to the ETC
56
What do the electrons from reduced CoQ get passed on to?
Cytochrome c | (consist of a Heme group & Protein)
57
How is a cytochrome changed when it accepts an electron?
The IRON of the heme group is reduced from Fe3+ to Fe2+
58
What is Thiamine pyrophosphate (TPP)? What is it made from?
Derivative of Thiamine (B1) Formed from ATP and thiamine Deficiency = beri beri
59
What is the pentose phosphate pathway? Products? Rate limting enzyme?
2 pathways *_Oxidative_* phase - begins with ***glucose-6-phosphate*** \*\*Gl-6-Phos --\> Rib-5-Phos generates ***_2 NADPH_*** from 2NADP+\*\* *_Non oxidative_* - begins with ***ribulose-5-phosphate*** RLE: ***_Glucose-6-Phosphate Dehydrogenase_***
60
Number of NADH, FADH per molecule of glucose in the TCA cycle? Number of enzymes involved? What two things start the cycle?
one glucose, ***2 turns*** of the cycle. 6 NADH, 2 FADH, 8 enzymes Acetyl CoA & oxaloacetate
61
What happens to GTP produced from the Krebs cycle?
GTP --\> ATP by the enzyme ***Nucleoside Diphosphokinase*** It is always converted afterwards because ***GTP cannot be used as an energy source*** for many cell functions (GTP is specific to protein synthesis and gluconeogenesis)
62
What is temporal summation?
Temporal summation occurs when a ***single neuron*** fires many ***excitatory post synaptic potentials*** (EPSPs). If the summation crosses the threshold potential, then the post-synaptic cell will depolarise and generate and action potential.
63
What is spatial summation?
Spatial summation occurs when ***different neurons*** synapse with the cell body of a neuron and ***they each fire EPSPs***.
64
When does an Inhibitory postynpatic potential occur?
It occurs when a presynaptic membrane release a neurotransmitter that causes the ***opening of Cl- channels*** in the postsynaptic membrane and ***hyperpolarisation***.
65
What does Frequency potentiation mean?
It occurs when ***many action potentials*** arrive at the ***presynaptic membrane***, leading to a ***larger release of neurotransmitter*** from the presynaptic cell. The postsynaptic membrane is therefore more likely to depolarise.
66
Under what conditions will a reaction occur spontaneously?
if delta G = -ve (exothermic) A reaction will only proceed if there is an ***increase in disorder*** (delta S) within the system
67
Name the types of _proper_ connective tissue. Name the types of _special_ connective tissue.
proper = Loose, Dense regular, Dense irregular special = adipose, blood, cartilage, bone
68
Fibro blasts are the active cells in connective tissue. They secrete ECM including fibres such as \_\_, \_\_, \_\_, \_\_?
collagen, elastin, reticulin, ground substance
69
Sickle Cell Anaemia = change of __ to __ ? (amino acids)
***Glutamic acid*** --\> Valine
70
Location and function of: GLUT1 GLUT2 GLUT3 GLUT4 GLUT5
GLUT1 - all cells - ***basal uptake*** GLUT2 - liver & pancreas - ***glucose uptake (from blood)*** GLUT3 - all cells - ***basal uptake*** GLUT4 - muscle & adipose - \****insulin*** sensitive\* GLUT5 - S.intestine - ***fructose*** (F.diff)
71
What is the action of 'Enolase' enzyme?
Takes water out i.e. dehydration
72
What makes up ATP?
Adenine, Ribose, 3 x Phosphate
73
What is the nernst equation? units? Simplified version? (under what conditions?) units?
_Normal_: \*\* ***-ve*** \*\*, Temp in ***K***, z = charge of ion units: v --\> x 1000 = mv _Simplified_ - at ***37oC***. units: mv
74
Convert oC --\> Kelvin.
+273.15
75
How would you calculate a 95% reference range using a given mean and SD?
Exclude top and bottom 2.5% Range = (mean***-***1.96SD) to (mean***+***1.96SD)
76
Two pathways for glucose?
2 x (pyruvate --\> acetyl CoA) 2 x (pyruvate --\> lactate)
77
Link reaction. How many are made per glucose molecule? NADH ATP CO2
(1 x glucose --\> ***2 x pyruvate***) 2 NADH 0 ATP 2 CO2
78
TCA cycle How many are made per glucose molecule? NADH FADH2 ATP CO2
***6*** NADH ***2*** FADH2 ***0*** ATP (_2 GTP_ --\> converted to ATP) ***4*** CO2
79
What is ketogenesis?
The production of ketone bodies (highly acidic) from acetyl coa.
80
What is the 'committed' step in glycolysis? How is it regulated in skeletal muscle?
***_PFK_*** Inhibited by *_low pH_* (as a result of increased lactic acid). This will denature the enzyme, preventing more lactic acid from being produced. *_ATP allosterically inhibits_* at high concentrations but this will be removed by the high ***_AMP_*** present.
81
What is the final end product of beta oxidation? How does it enter the TCA cycle?
Beta oxidation creates acetyl CoA & acyl CoA until all carbons of acyl CoA are gone. There will be a three carbon end product ***_Propinyl CoA_*** produced if the fatty caid chain contains an odd number of carbons. Propinyl CoA is converted to Succinyl CoA which enters the TCA cycle.
82
Place in order (excitation contraction): ## Footnote 1) Depolarisation spreads to the T tubules 2) Ca2+ is released from the sarcoplasmic reticulum 3) ACh released from alpha motor neurons 4) Signal is passed to the terminal cisternae 5) Binding of ACh to receptors on the sarcolemma
5) Binding of ACh to receptors on the sarcolemma 3) ACh released from alpha motor neurons 1) Depolarisation spreads to the T tubules 4) Signal is passed to the terminal cisternae 2) Ca2+ is released from the sarcoplasmic reticulum \*\****_T tubules_*** are imaginations of the *_sarcolemma_* (cell membrane) into the muscle fiber \*\****_Terminal Cisternea_*** are expanded portions of the *_sarcoplasmic reticulum_* that come in close proximity to the T tubules.

Year 1 (PCS & Cases 1-6) (13 decks)

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