PCOS Flashcards
1
Q
Diagnostic criteria for PCOS?
A
- Hyperandrogenism
- ovulatory dysfunction
- polycystic ovaries (in one or both ovaries, either 12+ follicles measuring 2-9mm or increased ovarian volume (greater than 10cm3)
2
Q
Facts on androgens?
A
75% testosterone made in ovary. Secretes androstenedione and dihydrotestosterone=most potent androgen, results primarily from intracellular 5-alpha reduction of testosterone.
3
Q
What are 3 treatments for hirsutism?
A
Spironolactone, Flutamide, Finasteride
4
Q
What is spironolactone?
A
Spironolactone: androgen-R antagonist. Aldosterone antagonist and diuretic. Can cause menstrual irregularity.
- SE: vomiting, dizziness, bleeding, mastalgia
5
Q
What is finasteride?
A
Finasteride: inhibits 5-alpha reductase (which converts testosterone into DHT-most potent androgen). Teratogenic in male fetuses.
6
Q
What is Flutamide?
A
Flutamide=androgen-R agonist. Common side effect=dry skin, rarely hepatitis.
