PCC1-SfP - Structure of Drugs Flashcards
The estimated yield of an API extracted from a sample of bark is 0.06 %. How many grams would be yielded from 200 kg of bark? (No calculator allowed)
120g
With regards to the general drug development process, which statement is INCORRECT?
Preclinical testing involves assessing the safety of drugs in humans
Which statement is correct?
A hit molecule is one shown to interact with the biological target of interest
Chemoinformatics is an important part of the drug discovery and design process. Which is INCORRECT?
Chemoinformatics techniques can be automated using robotic technologies
The use of chemoinformatics within the drug design and development process offers a number of advantages and potential disadvantages. Which is INCORRECT?
Chemoinformatics replaces the need to carry out clinical trials
Which is INCORRECT when considering computer-aided drug design and molecular docking?
Computer-aided drug design is able to construct a detailed 2-dimensional model of the target and investigate interactions with a natural ligand
What statement is INCORRECT?
Acute toxicity testing is used to highlight specific efficacy differences between animal species
What is INCORRECT when considering NICE?
NICE is involved in the licensing of new drugs
What type of organisation is NICE?
A UK organisation
What is the role of NICE?
TO carry out a cost vs benefit analysis for NHS usage of drugs
What does NICE stand for?
National Institute for Health and Care Excellence
Does a drug need to be approved by NICE?
A drug does NOT need to be approved by NICE to be available on prescription in the UK
In relation to the WHO Essential Medicines List, what is INCORRECT?
The WHO Essential Medicines List only includes natural/naturally derived products.
What does the WHO Essential Medicines List contain?
Drugs that satisfy the health care needs of the majority of the population
Does the WHO Essential Medicines List contain a number of drugs inspired from natural products?
YES
