PCC1-pharmacokinetics, dynamics and metabolism Flashcards
What is an example of a cytochrome P450 enzyme inducer?
Rifampicin
Which statement regarding bound and free drugs is INCORRECT?
drug protein binding is of high specificity and results in pharmacological effects
What is the fastest route of drug administration?
intravenous
A drug showing first order elimination kinetics from a one compartment model has a half-life of 6 hours. This means that…
after 100 mg i.v. that 50 mg will be eliminated in 6 hours
Clearance is a measure of…?
the rate of elimination of the drug
Which of the following routes of drug administration involves “first-pass” metabolism?
oral
Acidic drugs…?
in an acidic environment are lipid soluble and readily pass across membranes
Movement of drugs by passive diffusion across membranes…?
requires that the molecule is relatively lipid soluble
The apparent volume of distribution of a drug in humans…?
can exceed the volume of water in the body
The metabolism (or biotransformation) of chemical substances in the body…?
may increase pharmacological activity
