PCC1- drug targets and amino acids/proteins cycle

Question 1

What are the types of bonds in the i) primary and ii) tertiary structures of a protein respectively?

Answer 1

i) peptide bond, ii) hydrogen bond, ionic bond, hydrophobic, disulphide bridge

Question 2

Which set of amino acids are the essential amino acids that must be sourced from the diet by adults and growing infants?

Answer 2

Methionine, Arginine, Histidine, Tryptophan

Question 3

Describe the structure of a parallel β-pleated sheet?

Answer 3

Polypeptide chains run in the same direction and hold together by hydrogen bonds

Question 4

Calcitonin is an important hormone protein involved in the regulation of?

Answer 4

blood calcium

Question 5

Collagen is the most abundant protein in the body. What is the function of collagen?

Answer 5

tissue structure

Question 6

G protein alpha subunits?

Answer 6

contains intrinsic GTPase activity

Question 7

What is the sequence of events results from the activation of intracellular receptor?

Answer 7

binding of activated ligand/receptor complex to DNA

Question 8

Ligand-gated ion channels typically mediate responses in..?

Answer 8

milliseconds

Question 9

Tyrosine kinase receptors contain.?

Answer 9

an alpha helix

Question 10

What is the following sequence of events results from G-protein coupled receptor activation?

Answer 10

Activation of the target by GTP bound alpha subunit