PBL Drugs

Question 1

Hydrochlorothyazide

Answer 1

Inhibits the Na Cl symporter in the distal convoluted tubule. Leads to loss of Na, Cl, H2O. Would lead to an increase in renin release. Safe old drug

Question 2

Losartan

Answer 2

Inhibits Angiotensin II receptor. Prevents vasoconstriction in the vessels

Question 3

Simvastatin

Answer 3

Statin Inhibits HMG CoA Reductase preventing synthesis of endogenous cholesterol. Lowers LDL by 67%.

Question 4

Niacin

Answer 4

REDOX reactions, leads to an increase in HDL decreased mobility of fatty acids.

Question 5

Ezetimide

Answer 5

Inhibits the absorption of cholesterol at the brush border of the Intestines

Question 6

Gemfibrozil

Answer 6

Upregulates lipoprotein lipase leading to increased tryglyceride clearance.

Question 7

Cholestyramine

Answer 7

Bile acid resin which prevents reabsorption of bile acids in the intestines to lower LDL, would cause fat soluble vitamin deficiency. not as good as a statin.

Question 8

Ace inhibitors

Answer 8

inhibit angiotensin converting enzyme. All end in -pril

Question 9

Spironolactone

Answer 9

Inhibits aldosterone receptor in the distal convoluted tubule leading to decreased production of the Na K ATPase.

Question 10

Amilodipine

Answer 10

Class IV dihydropurine which blocks calcium channels in the vasculature leading to decreased blood pressure

Question 11

5 Classes of oof drugs for treatment of dyslipidemias.

Answer 11

Statins, bile acid residues, niacin, fibrostatins, Cholesterol uptake inhibitors

Question 12

Clonidine

Answer 12

Centrally acting a2 receptor agonist which leads to sympathetic feedback causing decreased sympathetic release leading to decreased CO and TPR

Question 13

Prazosin

Answer 13

a1 receptor antagonist causing vasodilation

Question 14

Left ventricular Hypertrophy

Answer 14

V1 or 2 s wave plus 5 or 6 S wave > 35mm