Diuretics and ADH

Question 1

Furosemide

Answer 1

Inhibits the NKCC2 pump in the ascending thick loop of Henle.

Question 2

Bumetanide

Answer 2

Inhibits the NKCC2 pump in the ascending thick loop of Henle.

Question 3

Chlorthalidone

Answer 3

Thiazide diuretic which inhibits NaCl transporter in the distal convoluted tubule
AE: hyperglycemia from suppressing B cell insulin release, hypokalemia and natremia. Hyper uricemia, lipidemia glycemia

Question 4

Hydrochlorothiazide

Answer 4

Thiazide diuretic which inhibits NaCl transporter in the distal convoluted tubule
AE: hyperglycemia from suppressing B cell insulin release, hypokalemia and natremia. Hyper uricemia, lipidemia glycemia

Question 5

Metalazone

Answer 5

Thiazide diuretic which inhibits NaCl transporter in the distal convoluted tubule
AE: hyperglycemia from suppressing B cell insulin release, hypokalemia and natremia. Hyper uricemia, lipidemia glycemia

Question 6

Spironolactone

Answer 6

Inhibits aldosterone receptor preventing Na/K atpase in the distal convoluted tubule shown to improve survival in patients with heart failure.
AE: gynecomastia, hyperkalemia and chloremia

Question 7

Amiloride

Answer 7

Inhibits Na exchange for Ka nd H in the cortical collecting duct. Less K wasting

Question 8

Triamterene

Answer 8

Inhibits Na exchange for Ka nd H in the cortical collecting duct. Less K wasting

Question 9

Vasopressin

Answer 9

Naturally occurring hormone made in the posterior pituitary to produce aquaporins via G protiein receptor Gsalpha leading to increased water uptake and more concentrated urine.

Question 10

Desmopressin

Answer 10

A synthetic vasopressin administered nasally which is used for bed wetting and diabetes insipidus by recruiting aquaporins via Gsalpha receptors.

Question 11

Demecocycline

Answer 11

an antibiotic with some affect as an ADH agonist

Question 12

Mannitol

Answer 12

Is an osmotic diuretic because it cannot be reuptaken by the kidney. draws out a lot of water as it is excreted.

Question 13

Acetazolamide

Answer 13

Inhibits carbonic anhydrase preventing the production of carbonate. which limits substrate for the Na/H antiporter. Used for glaucoma and to produce urinary alkalinization.

Question 14

Allopurinol

Answer 14

inhibits xanthine oxidase reducing uric acid formation.

Question 15

Probenicid

Answer 15

Inhibits organic acid transporters to facillitate excretion and inhibits urate reabsorbtion

Question 16

Colchicine

Answer 16

Microtubule with antiinflammatory properties

Question 17

Sulfinpyrazone

Answer 17

Inhibits organic acid transporters to facillitate excretion and inhibits urate reabsorbtion