Adrenergic Agonsits

Question 1

Epi synthesis pathway

Answer 1

Tyrosine to DOPA to Dopamine to NE to Epi

Question 2

B1 receptor

Answer 2

Gs alpha. leads to increased cAMP. Cholera toxin acts on this receptor in intestines and reverses pump. Is on the heart, stimulation by epi, NE, isoproterenol and B1 selective is dobutamine to cause increased HR and contractility. c

Question 3

B2 receptor

Answer 3

Gs alpha increased cAMP. Is on the vasculature and bronchioles and stimulation by Epi (not NE), isoproterenol, and albuterol to lead to vasodilation and brochorelaxation

Question 4

a1 receptor

Answer 4

Gq-> phospholipase C, smooth muscle contraction on the vasculature, and stimulated by epi, NE, phenylephrine to cause vasoconstriction.

Question 5

a 2 receptor

Answer 5

G0 decreased cAMP. Is on nerve cell terminals and in the brain as a feedback mechanism. It is stimulated by epi, NE, and clonidine and leads to decreased NE release from body and less sympathetic activity.

Question 6

Reserpine

Answer 6

inhibits the pump which puts NE into vesicles, leading to less NE available to be released into the synapse.

Question 7

MAOI

Answer 7

Monoamine oxidase inhibitor- prevents NE breakdown leading to more effect of NE. Examples selegiline, procarbazine.

Question 8

Tyramine

Answer 8

Reverses the direction of the axoplasmic catecholamine transporter and all free NE(not in vesicles) in the neuron will be pumped into the synapse.

Question 9

Amphetamine

Answer 9

Reverses the direction of the axoplasmic catecholamine transporter and all free NE(not in vesicles) in the neuron will be pumped into the synapse.

Question 10

Cocaine

Answer 10

inhibits the axoplasmic catecholamine transporter preventing reuptake of NE into the neuron.

Question 11

Ephedrine

Answer 11

Reverses the direction of the axoplasmic catecholamine transporter and all free NE(not in vesicles) in the neuron will be pumped into the synapse.

Question 12

Guanethidine

Answer 12

leads to degradation of NE stores by inducing release from the vesicle and degradation by MAOI, reducing sympathetic stimulation.

Question 13

Pargyline

Answer 13

Monoamine oxidase inhibitor, can potentiate the action of catecholamines.

Question 14

Dobutamine

Answer 14

B1 selective agonist contraindicated in a fib.

Question 15

Phenylephrine

Answer 15

a1 selective agonist leading to smooth muscle contraction, and as an oral decongestant, prostate dilation/ relaxation

Question 16

Doxazoin

Answer 16

AZOINs are a1 receptor antagonists.

Question 17

Metaproterenol

Answer 17

B2 agonist, Leads to bronchodilation and vasodilation.

Question 18

Terbutaline

Answer 18

B2 agonist, Leads to bronchodilation and vasodilation.

Question 19

Albuterol

Answer 19

B2 agonist, Leads to bronchodilation and vasodilation.

Question 20

Ritodrine

Answer 20

B2 agonist, Leads to bronchodilation and vasodilation.

Question 21

Salmeterol

Answer 21

B2 agonist, Leads to bronchodilation and vasodilation.

Question 22

Clonidine

Answer 22

a2 agonist, centrally acting, negative feedback loop for NE release

Question 23

alpha-methyldopa

Answer 23

a2 agonist, centrally acting, negative feedback loop for NE release. Antihypertensive safe to use in pregnancy

Question 24

Guanabenz

Answer 24

a2 agonist, centrally acting, negative feedback loop for NE release

Question 25

Epinephrine

Answer 25

agonizes all sympathetic receptors. When a1 receptors are antagonized, see a drop in blood pressure more than normal because B2 receptors are agonized leading to vasodilation.

Question 26

Terazosin

Answer 26

A1 antagonist leads to vasodilation.

Question 27

Norepinephrine

Answer 27

Antagonizes a1 and B1 receptors, no effect on B2.

Question 28

Isoproterenol

Answer 28

B1 and B2 agonists. would lead to vasodilation and tachycardia.

Question 29

Dopamine

Answer 29

Positive ionotrope for B1, vasodilator in renal and mesenteric vasculature at lower conc, leads to vasoconstriction at higher doses.

Question 30

Pseudoephedrine

Answer 30

stereoisomer of ephedrine. Release of NE via reversing the axoplasmic catecholamine transporter

Question 31

guanadrel

Answer 31

leads to degradation of NE stores by inducing release from the vesicle and degradation by MAOI, reducing sympathetic stimulation.

Question 32

Nicotine

Answer 32

Activates nicotinic receptor which leads to NE release from the post synaptic nerve in the sympathetics.