PBL - antacids + PPIs Flashcards
1
Q
4 indications of antacid use
A
- gord
- indigestion
- stomach ulcers
- gastritis
2
Q
name 2 common types of antacid
A
• aluminium hydroxide • magnesium carbonate • magnesium trisilicate • magnesium hydroxide • calcium carbonate sodium bicarbonate
3
Q
when should antacids be taken + why
A
with or after food - as this is when the sxs appear
4
Q
how do antacids work?
A
they are bases which neutralise stomach acid
5
Q
2 SE of antacids
A
- diarrhoea/constipation
- nausea/vomiting
- abdo cramps
- flatulence
6
Q
2 examples of PPIs
A
omeprazole
lansoprazole
7
Q
general function of a PPI drug
A
inhibits gastric acid secretion
8
Q
which type of cells host the gastric acid pump
A
parietal
9
Q
by what process does the proton pump wprk?
A
active transport
10
Q
3 ligands which control acid secretion
A
- acetylcholine
- gastrin
- histamine
11
Q
how does histamine increase acid secretion
A
- attaches to H2 type receptor
- activates adenylate cyclase
- atp in to cAMP
- PKA activation
- PKA - phosphorylates proteins involved in proton pump
12
Q
how to PPIs work?
A
covalently bind to proton pumps - cause a conformational change in shape of the enzyme so H+ cannot be secreted into the lumen
13
Q
2 examples of when PPIs are used
A
- GORD
- NSAID associated ulcers
- peptic ulcers
- reflux oesophagitis
14
Q
OTC dose of PPIs
A
10mg
15
Q
Px dose of PPIs
A
30mg, od, 4 weeks
