PBL 7

Question 1

Tumor Suppressor Genes examples

Answer 1

1. RB gene (retinoblastoma) -> Gene that is a prototype tumor suppressor gene. Encodes a nuclear protein that acts as a cell cycle control checkpoint at the G1 phase
2. p53 gene

Question 2

(Proto-)Oncogen examples:

Answer 2

1. RAS (G-protein transmitter) -> Keeps hydrolyzing GTP to GDP, therefor making the surface protein overactive, 30% of all human cancers.
2. EGF (Epidermal growth factor) -> Deletion makes this overactive,
3. Myc protein, general TF -> responsible for cyclin production -> overactive cell proliferation

Question 3

Why p53 mutations is so crucial in causing cancer

Answer 3

• p53 controls cell cycle arrest, senescence and apoptosis

- If things had