PBL Flashcards
1
Q
Henoch-Schonlein Purpura
A
- HSP
- Most common vasculitis in kids
- Due to IgA immune complex deposition
- Presentation: palpable purpura on buttocks and legs
- GI pain and bleeding
- Hematuria (IgA nephropathy)—involvement of kidney is very high yield
- Usually occurs following an upper respiratory tract infection—one of the antibodies you generate is IgA
- IgA deposition drives the vasculitis!
- Disease is self-limited
- If severe, treat with steroids
2
Q
Nephrotic vs. Nephritic
A
Think: Nephrotic-Loss of protein due to flattening of podocytes (disrupting filtration system).
Nephritic: think loss of blood (example-Immune complex deposition)
3
Q
Most common UTI bug?
A
E Coli
4
Q
Kawasaki Disease rash?
A
Palms and soles
Small children
5
Q
2 large vessel vasculitides?
A
Giant Cell
Takayasu
6
Q
Site of action of Furosemide?
A
NKCC in Thick Ascending Loop of Henle
7
Q
Site of action of thiazides?
A
Na/Cl in Distal Tubule
8
Q
Where is 100 % of glucose reabsorbed?
A
Proximal Tubule
