Foundations Flashcards
Xeroderma Pigmentosusm. Tell me about it.
Autosomal recessive Disease of defective DNA repair Increased sensitivity to UV radiation Shortened life span Increase chance of melanoma, squamous cell carcinoma, basal cell carcinoma
What does histone methylation do
Makes DNA mute
What does histone acetylation do
Makes DNA active
Form of chromatin that is transcriptionally active
Euchromatin
nucleotides with 2 rings
purines (AG)
GC or AT bond stronger? why?
G-C….3 H bonds
AT only has 2 H bonds
What amino acids are necessary for purine synthesis?
GAG
Glycine, Aspartate, Glutamine
Difference between nucleoside and nucleotide?
NucleoSide: Base + Sugar
NucleoTide: Base + sugar + PhosphaTe
What enzyme converts ribonucleotides to deoxyribonucleotides?
Ribonucleotide reductase
What 2 metabolic pathways involve Carbamoyl phosphate?
Pyrimidine synthesis
Urea cycle
What drug inhibits dihydroorotate dehydrogenase?
Leflunomide
What drugs inhibit IMP dehydrogenase?
Mycophenolate
Ribavirin
What drug inhibits ribonucleotide reductase?
Hydroxyurea
What drug and what prodrug inhibit de novo purine synthesis?
6-mercaptopurine
Azathioprine
What drug inhibits dUMP–>dTMP?
5-Fluorouracil
Inhibits thymydilate synthase
