PBL 1 - cardiology Flashcards
what is Marfan’s syndrome
- disorder of the body’s connective tissue, a group of tissues that support the structure of the body and support internal organs and other tissues
- gene defect which leads to abnormal production of a protein called fibrillar
what are some typical characteristics of Marfan’s syndrome
- being tall
- abnormally ling and slender limbs, fingers and toes
- heart defects
- lens dislocation = vision impaired
what can happen to the heart in Marfan’s syndrome
- walls of the aorta are weakened
- can cause aorta to enlarge and possibly rupture
- can cause mitral or tricuspid valves to not close properly causing blood to leak back through the valve
what medication are those with Marfan’s syndrome given
- beta blockers
- used to treat hypertension
- but most people with this condition have hypotension
- in this case, beta blockers help slow down the heart rate and decrease the strength of heartbeat, which in turn helps slow down enlargement of the aorta
what medication does those with Marfan’s syndomre take
- bisoprolol
what are the dental considerations for patients with Marfan’s syndrome
- risk of infective endocarditis = antibiotic prophylaxis ?
- interactions of bisoprolol
what are some of the interactions of bisoprolol
- with adrenaline = increase risk of hypertension and bradycardia
- with alcohol = increase risk of hypotension
- with lidocaine = predicted to increase risk of CV adverse effects
what are contra-indications for bisoprolol
- asthma
- bronchospasm
- COPD
- heart failure
what are some side effects of bisoprolol
- constipation, bradycardia, depression, confusion, HF, fatigue, vomiting
what is infective endocarditis
an infection of the inner lining of the heart (endocardium)
- can occur in those with a congenital heart disease, or a prosthetic valve
what pathogen is commonly seen causing IE
- streptococci viridans
- or staph aureus
what might you have to do for patients with a risk of IE
- antibiotic prophylaxis
when is AB prophylaxis recommended
- it is not routinely recommended for people undergoing dental procedures
- only a sub-group of those at increased risk
which patients will receive AB prophylaxis
- prosthetic valve
- previous IE
- congenital heart disease
what procedures would AB prophylaxis be needed
- only invasive procedures