PBC AND PSC

Question 1

antibodies of PBC 6

Answer 1

1. IgM
2. antimitochondrial antibody-AMA
3. Anti-centromere
4. ANA anti-nuclear
5. PDC-E2
6. ASMA

Question 2

which gene is linked to PBC

Answer 2

HLA DR8

Question 3

PSC antibodies

Answer 3

ANCA

IgM

Question 4

female to male ratio for both

Answer 4

pbc= 10:1

PSC=1:3

Question 5

age of onset for both

Answer 5

pbc =middle aged women

psc=20-40s men

Question 6

symptoms of PBC

Answer 6

fatigue
pruritus
dry eyes
dry mouth

Question 7

symptoms of PSC

Answer 7

progressive obstructive jaundice
triad of cholangitis
-fever
-jaundice
-RUQ pain

Question 8

site of involvement for both

Answer 8

pbc=interlobular

psc=inter and extra

Question 9

pbc cause of obstruction

Answer 9

-granulomatous inflammation destroying bile ducts

Question 10

psc cause of obstruction

Answer 10

inflammation, fibrosis with sclerosis (hardening and narrowing of the bile ducts)

Question 11

what is pbc assoc too

Answer 11

sjorgren
RA
SLE

Question 12

what is psc assoc. too

Answer 12

IBD

uc and cd

Question 13

Which one has an increased risk of cancer

Answer 13

psc risk cholangiocarcinoma

Question 14

treatment for pbc and psc

Answer 14

no cure for either
pbc=ursodeoxycholic acid to slow down rate
and colestyramine for pruritus

Question 15

which ANA for pbc is assoc to poorest prognosis

Answer 15

anti gp 120

Question 16

imaging test colour for anti-mitochondrial antibodies

Answer 16

green immunofluorescence

Question 17

is transplant a cure

Answer 17

no