PB#135: Second-Trimester Abortion Flashcards
Potential circumstances that could lead to eAB in 2nd tri (4)
Delay in suspecting/testing for pregnancy, delay in obtaining insurance/funding, delay in obtaining referral, difficulty locating/traveling to available provider
Factors associated w/ higher rates of seeking 2nd tri eAB (3)
Poverty, lower education level, multiple disruptive life events
Percentage of pts who choose to terminate pregnancies if major anatomic/genetic anomalies are detected in 2nd tri
47-95%
Possible OB/medical indications for 2nd tri termination/ evacuation (4)
Pre-E, PPROM, pregnancy failure <20wga, IUFD
IUFD rate at >20wga
6.22 deaths per 1,000 live births + fetal deaths
Demographics w/ higher IUFD rates (3)
Teenage, AMA, Black/Hispanic/Native American pts
Two general management options for 2nd tri eAB
Medical, surgical
Most common method of performing 2nd tri eAB
D&E (~95% of cases)
Percentage of abortion providers that offer services at >12wga, percentage of abortion providers that offer services at >20wga
64%, 23%
Percentage of clinics providing 2nd tri eABs that also offer medical termination
33%
Description of “partial-birth abortion”; year that federal ban on “partial-birth abortion” was passed
Vaguely defined, though widely interpreted as ban on intact D&E unless IUFD occurs prior to surgery; 2003
Reason multiple states have banned eABs at >20wga; what medical evidence suggests to refute this
Concerns related to fetal pain; fetal perception of pain may not occur until 3rd tri
Methods for cervical prep (2)
Osmotic dilators, prostaglandin analogs
Most common prostaglandin analog used in cervical prep
Miso
Reason cervical prep is recommended prior to D&E
Reduce risk of cervical trauma
General technique used in D&E
Aspirating amniotic fluid and removing fetus w/ forceps through cervix and vagina, fetal disarticulation/dismemberment commonly occurs, final suction curettage performed to ensure complete evacuation
General technique used in intact D&E
Requires more advanced cervical dilation over several days, followed by removal of intact fetus except for possible decompression of calvarium
When is intact D&E preferable?
When preservation of fetal anatomy is desired
Lower risks associated w/ intact D&E (2)
Uterine perf, infection 2/2 retained fetal tissue
Disadvantages of 2nd tri induction-termination vs D&E (3)
Less cost-effective, associated w/ greater risk of complications (ie incomplete AB), may be prolonged
Conditions in which medical induction-termination may be preferable over D&E (3)
Pregnancies w/ fetal anomalies, genetic disorders, maternal health issues
Meds/Techniques for medical abortion (5)
Prostaglandin analogs (miso), mife, osmotic dilators, Foley catheters, pit
Why is miso (alone or in combo) recommended over other agents alone (3)?
High efficacy, low cost, ease of use
Mife + vaginal miso induction-termination protocol
Mife 200mg PO > miso 800mcg vaginally 24-48h later > miso 400mcg vaginally/sublingually q3h x5 doses max
Next step if eAB has not completed after 5 doses of miso under mife > vaginal miso induction-termination protocol
Pt may be rest x12h then resume cycle again
Mife + buccal miso induction-termination protocol
Mife 200mg PO > miso 400mcg bucally 24-48h later and q3h x5 doses max
Miso only induction-termination protocol w/o miso loading dose (if mife unavailable)
Miso 400mcg vaginally/sublingually q3h x5 doses max
Next step if eAB has not completed after 5 doses of miso under miso only induction-termination protocol
Pt may be rest x12h then resume cycle again
Superior route of miso placement for nullip pts
Vaginal (over sublingual)
Miso only induction-termination protocol w/ miso loading dose (if mife unavailable)
Miso 600-800mcg vaginal loading dose > miso 400mcg vaginally/sublingually q3h
Induction-termination protocol if both mife and miso unavailable
Pit 20-100U IV q3h > 1h w/o pit (to allow for diuresis) > dose slowly increased to max of 300U over 3h
Why is high-dose pit not commonly used in 2nd tri?
Inefficient uterine response to pit 2/2 fewer oxytocin receptors at this gestational period
Do osmotic dilators provide added benefit to induction w/ prostaglandin analogs?
No
Most effective regimen for 2nd tri medical eAB; percent efficacy of this method
Mife > miso; up to 91% within 24h of initiation of miso
Rare alternative method of performing 2nd tri eAB (instead of medical eAB or D&E); indications for this method (2)
Hyst/Hysterotomy; if other methods are contraindicated or have failed
Does inducing fetal demise increase safety of 2nd tri medical/surgical eAB?
No, although limited evidence does suggest that induced fetal demise prior to medical eAB may shorten induction time
Techniques used to case fetal demise (3)
Umbilical cord division, intraamniotic/intrafetal digoxin injection, fetal intracardiac KCl injection