Patient Experience

Question 1

HRQOL

Answer 1

Health Related Quality of Life
- Sometimes is better to use than morbidity and mortality

Ex: Depression (Mood), Arthritis (Pain, Function)

Question 2

JAMA Guide to PROs

Answer 2

1. Is the measurement of HRQOL important
2. Is the study valid
   - Primary Guide:
   - Secondary Guide
3. What were the results
4. How can the results be applied to patient care

Question 3

Primary Guide

Answer 3

• Did the investigators measure outcomes that patients find important
• Were their instruments reliable
• Do the instruments relate to other instruments as expected

Question 4

Secondary Guide

Answer 4

Did the investigator omit any important aspects of the patients’ HRQOL

Question 5

High Quality Trial of Health Status
(Study Design)

Answer 5

1. Research question related to health status
2. Appropriate instrument to measure health status
3. Psychometric Properties
4. Define Minimal Important Difference
5. Sample Size
6. Allocation Concealment and Blinding

Question 6

High Quality Trial of Health Status
(Analysis Reporting)

Answer 6

1. Missing Data
2. Analyzing Outcomes

Question 7

Defined research question to health status
- Attributes of High Quality

Answer 7

• Primary/Co-primary outcome is related to a change in health status
• Defines what is being measured and why
• Tells us how it will be calculated

Question 8

Appropriate instrument to measure health status
- Attributes of High Quality

Answer 8

Look for consistientcy and differences between tools in the study and other studies

Question 9

Psychometric Properties of the Instrument
- Face Validity

Answer 9

The extent the instrument appears to be measuring what it intends to measure

Question 10

Psychometric Properties of the Instrument
- Content Validity

Answer 10

How well the instrument covers all health relevant parts it aims to measure

Question 11

Psychometric Properties of the Instrument
- Construct Validity

Answer 11

The extent that the response of the instrument matches with that of other instruments the way it should

Question 12

Psychometric Properties of the Instrument
- Reliability

Answer 12

The extent the instrument produces the same score when repeated on the same stable patient

Question 13

Psychometric Properties of the Instrument
- Responsiveness

Answer 13

The ability of the instrument to detect changes in individuals who have changed over time

Question 14

Psychometric Properties of the Instrument
- Precision

Answer 14

The extent the instrument is free from random error

Question 15

Psychometric Properties of the Instrument
- Reproducibility

Answer 15

Inter-rater reliability and Intra-rater reliability should be high
- Should see similar results when repeating

Question 16

Psychometric Properties of the Instrument
- Internal Consistency

Answer 16

Different items within a single domain are homogenous or cohesive in their response
- There is correlation between the different items on the scale

Question 17

Psychometric Properties of the Instrument
- Interpretability

Answer 17

The extent the instruments score is easily understood

Question 18

How to calculate sample size required to demonstrate clinically meaningful effect

Answer 18

Use Minimum Clinically Important Difference to calculate sample size needed