PATHOPHYSIOLOGY OF PSORIASIS

Question 1

• multifactorial, chronic, immune-mediated inflammatory condition (Agarwal et al., 2023)
• chronic proliferative and inflammatory
  condition of the skin (Nair & Badri, 2023)
• common chronic, persistent or relapsing, scaling skin condition (Hammer & McPhee, 2014)

Answer 1

PSORIASIS

Question 2

Characterized by:
- Sharp margination and bright erythematous plaques
- Nonconfluent whitish or silvery scales
- Desquamation (skin shedding)
- Itching

Answer 2

PSORIASIS

Question 3

Psoriasis commonly occurs on:

Answer 3

• Face - Feet
• Scalp - Knees
• Palms - Elbows

Question 4

5 MAJOR TYPES OF PSORIASIS

Answer 4

1. Plaque psoriasis
2. Guttate psoriasis
3. Erythrodermic psoriasis
4. Pustular psoriasis
5. Inverse psoriasis

Question 5

• Most prevalent type,
  affecting 80% to 90% of
  patients
• Erythematous plaques with
  silvery scales
• Commonly affects extensor
  surfaces (elbows, shins,
  knees, scalp, back)

Answer 5

PLAQUE PSORIASIS (Psoriasis vulgaris)

Question 6

• Erythematous, scattered, and
  scaly raindrop-shaped lesions
• Mainly found on trunk and
  back
• Often seen in children post
  upper respiratory tract
  infections (streptococcal
  pharyngitis)

Answer 6

GUTTATE PSORIASIS (Erruptive psoriasis)

Question 7

• Small, non-infectious pus-filled lesions with surrounding erythema
• Two types: localized and generalized
• Commonly occurs on palms, soles, and fingertips

Answer 7

PUSTULAR PSORIASIS

Question 8

• Least common but severe type
• Affects large areas (>90%) of the skin
• Presents with widespread inflammation, skin discoloration, and shedding

Answer 8

ERYTHRODERMIC PSORIASIS

Question 9

• Smooth, erythematous, sharply demarcated patches
• May be moist, macerated, and malodorous
• Occurs in skin folds (groins, armpits,
  intergluteal, inframammary regions)

Answer 9

INVERSE PSORIASIS
(Flexural or intertriginous psoriasis)