Pathophysiology Of Heart Failure Flashcards
What is heart failure?
“The inability of the heart to meet the demands of the body.” -i.e. deliver a blood volume (carrying oxygen / glucose ect.) that allows body tissues to function as required..
OR
“A clinical syndrome of reduced cardiac output, tissue hypoperfusion, increased pulmonary pressure and tissue congestion.” - see oedema / increased tissue fluid.
What enables the heart to work as an effective pump?
Input
One-way valves - competent and not stenosed
Chambre size - if small, not very much blood
Functioning muscle -cardiac myocytes much be normal and contract normally need adequate blood supply and normal muscle arrangement.
Output
What is the most common cause of heart failure?
Ischaemic heart disease (coronary heart disease).
- myocardial dysfunction e.g. through fibrosis (scarring), remodelling of muscle.
What are other causes of heart failure?
- Hypertension - increased afterload on ventricle and accelerates athlerosclerosis (inc. in coronary arteries). This leads to hypertrophy.
- Aortic stenosis - increased afterload on ventricles.
- Cardiomyopathies - e.g. hypertrophic / dialated.
- Arrhythmias
- Pericardial disease
- Other valvular myocardial structural diseases (acquired or congenital).
Rarely, can occur if a grossly elevated demand on cardiac output. E.g. sepsis, severe anaemia, thyrotoxicosis. This is high output. heart failure.
It is important to identify the underlying cause as this will direct the sebsequent treatment options.
How do we measure the ability of the heart to meet demands of the body?
CO = SV x HR
CO = volume delivered / min (expelled per ventricle/min)
SV = Volume ejected by a ventricle in a single beat
A normal heart will only eject about 2/3rds of its EDV.
What is the ejection fraction?
This is SV / EDV = fraction ejected.
So, it is the proportion ejected by the ventricles.
SV is only a fraction of the total volume within the ventricle at the end of diastole (EDV).
What three things affect stroke volume?
Pre-load - (Volume in ventricles at the end of diastole = EDV) ..this is the stretch on the ventricles just before comtraction.
After-load - Total peripheral resistance.
Myocardial contracility.
What is Frank-Starling’s Law?
More ventricular distension during diastole = greater volume ejected (SV) during diastole.
The bigger the venous return, the better the contraction as greater cardiac output.
Intrinsic property of cardiac myocytes… the greater they are stretched the greater their force of contraction.. up to a certain point…
How does the Frank-Starling Law change depending on the inotropic state of the heart?
Contractility of the heat can increase with increased sympathetic activity (curve shifted upwards and to the left)
Greater CO for a given LVEDP (more volume is forced out)
How can stroke volume be reduced?
Reduced preload (reduced EDV) Impaired filling of the ventricles during diastole
Reduced myocardial contractility - heat muscle is no longer able to produce same force of contraction for a given volume at the end of diastole.
Increased afterload - Increased pressure against the ventricles is contracting against. E.g. secondary aortic stenosis, chronic severe hypertension.
Why can the heart fail?
-
A filing problem (diastole) -‘Space’ available in ventricle to receive blood is reduced…EDV (pre-load) therefore reduced.
- Ventricular chambers too stiff / not relaxing enough
- Ventricular walls thickened (hypertrophied)
-
A contractility (ejection) problem (Systole) - ‘Space’ available in ventricles not an issue but poor ventricular contraction so unable to empty it as well.
- Can’t pump with enough force (for a given EDV)
- e.g. muscle walls thin / fibrosed, chambers enlarged (overstretched sarcomeres), abnormal or uncoordinated myocardial contraction.
What is HFrEF?
Heart failure with reduced ejection fraction.
Systolic dysfunction
More common
What is HFpEF??
Heart failure with preserved ejection fraction.
- Diastolic dysfunction.
- Nearly 50% patients
Types of heart failure
The..
What ventricle is most commonly involved in heart failure?
Most commonly involves the left ventricle - But, with subsequent involvement of the right ventricle.