Pathophys Flashcards
A disease characterized by cough producing sputum for at least 3 months and 2 consecutive years.
Chronic Bronchitis
Pathology of Chronic Bronchitis (4)
1) ^ size of mucus glands
2) goblet cell hyperplasia w/ low #cilia
3) Cilia dysfunction/disruption of mucus blanket
4) Bronchiolar narrow
Etiology Of Bronchitis
-Long term irritation of tracheobronchial (smoking)
Smoking ____ goblet cells to secrete ____ mucus
Stimulate, more
Smoke ____ ciliary action leading to _____
Inhibits, chronic cough
Characteristics of bronchitis
1) “blue Bloater” b/c decreased PaO2
2) ^ PaCO2, normal pH
3) Polycthemia
4) ^ PAP and RVH
Exacerbation of CB
1) Increased sputum
2) V/q Abn.
3) hypoxemia
4) Increase RR
Alveoli Hyperinflated
Emphysema
Characteristic of Emphysema
1) Pink Puffer
2) SOB and thin build
3) Accessory muscles
4) ^ A-P diameter chest
Etiology Of emphysema
Uncertain with age, smokers with CB
Prognosis of CB and Emphysema
- loss of lung fields
- Age is accurate predictor of death
Common cause of death in CB and Emphysema
CHF
resp failure
Pneumonia
PE
A disease characterized by increased responsiveness of trachea and bronchi to stimuli
Asthma
What happens during an asthma attack?
1) Lumen narrowed
2) Bronchial smooth muscle spasm
3) Inflammation of mucosa
4) Overproduction of mucus
Pathology of asthma
Allergic or intrinsic: for patients under 35
Nonallergic: pts over 35
Characteristics of asthma
1) nocturnal awakening
2) ^RR and accessory muscle
3) Wheezing
4) unproductive cough with chest tightness
Asthma attack lasting for hours
Status asthmatics
What happens in status asthmaticus?
Pt exhausted from breathing
- quiet chest
- medical emergency
- need to be ventilated
Characteristics of Restrictive Disorders
Lungs prevented from expanding fully
Symptoms of Restrictive Disorders
- SOB
- Non-productive cough
- very thin
How much VO2 need for work of breathing for normal and restrictive disorders.
5%
25%
Clinical Syndrome caused by acute lung injury and characterized by sever hypoxemia and increase alveoli permeability.
ARDS
Ards is associated with __.
Multi-organ Failure
Etiology of ARds
- Trauma
- Fat emboli
- Transplant
- Shock
- Pneumonias
- Aspiration
- Drugs
Chronic inflammation inducing fibrosis, destruction, and distortion of lung parenchyma.
Pulmonary fibrosis
Pulmonary fibrosis considered to be a progression of
Interstitial lung disease (IDL)
Most aggressive interstitial lung disease
IPF
Result of failure of lung repair process
Interstitial pulmonary fibrosis
Signs and Sxs of pulmonary fibrosis
- rapid shallow breathing
- dyspnea on exertion
- fatigue
- loss of appetite
- weight loss
- decreased breath sounds
- digital clubbing……
- cyanosis
Collapse of alveoli
Atelectasis