Pathoma - Bone Tumors Flashcards
Osteoma- location
facial bones
Osteoma- association
Gardner syndrome (FAP subtype)
Osteoid osteoma - location
long bones (cortex and diaphysis) benign tumor of osteoblasts
Osteoid osteoma - clinical presentation
bone pain that RESOLVES with aspirin
Osteoid osteoma - x-ray
bony mass (rim) w/ radiolucent osteoid core
Osteoblastoma - clinical presentation
like osteoid osteoma, but larger (>2cm) and pain DOES NOT resolve w/ aspirin
Osteochondroma - location
lateral projection of growth plate w/ cartilage cap
Osteochondroma - complications
can progress to chondrosarcoma
Osteosarcoma - cause
malignant proliferation of osteoblasts
Osteosarcoma - location
distal femur or proximal tibia (metaphysis)
Osteosarcoma - populations
teens or elderly
Osteosarcoma - associated with
retinoblastoma, Paget’s Dz, radiation exposure
Osteosarcoma - biopsy
large pleiomorphic cells producing osteoid
Giant Cell Tumor - location
epiphysis of long bones
Giant Cell Tumor - x-ray
“soap bubble” appearance
Ewing Sarcoma - cell type
poorly differentiated neural ectoderm cells
Ewing Sarcoma - location
diaphysis of long bones
Ewing Sarcoma - population
Boys <15
Ewing Sarcoma - associated translocation
t(11:22)
Ewing Sarcoma - x-ray
“Onion skin” appearance
Chondroma - location
medulla of hand/foot bones
Chondrosarcoma - location
medulla of pelvis or central skeleton
Metastatic tumors - appearance
osteolytic (punched out) lesions
exception: prostate (osteoblastic lesions)
Metastatic tumors - most common sources
Breast, Lung, Prostate
Most common benign tumor
osteochondroma
Osteochondroma - population
males <25
