Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Musculoskeletal > Musculoskeletal > Flashcards

Musculoskeletal Flashcards

1
Q

Aspirin MOA

A

Irreversibly binds cyclooxygenase (COX1+2)decreases thromboxane A2 and prostoglandin synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Aspirin - clinical use

A

low dose: decreased platelet aggregationintermediate dose: antipyretic/analgesichigh dose - anti-inflammatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Aspirin - AEs

A

GI bleeding, tinnitus, acute renal failureRisk of Reye’s syndrome in kids treated for viral infection (strep vs mono)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

NSAIDs - 5 common

A

Ibuprofen, naproxen, indomethacin, ketorolac, diclofenac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

NSAIDs - MOA

A

Reversibly bind cyclooxygenase (COX 1+2)-> blocks prostaglandin synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

NSAIDs - clinical use

A

antipyretic, analgesic, anti-inflammatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Specific NSAID used to close PDAs

A

Indomethacin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

NSAIDs - AEs

A

interstitial nephritis, GI ulceration/bleeding, renal ischemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

COX-2 inhibitors - common one

A

celecoxib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

COX-2 inhibitors - MOA

A

reversibly inhibits COX-2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

COX-2 inhibitors - clinical use

A

Rheumatoid and osteoarthritisshould spare gastric mucosa and platelet function (COX-1 dependent)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

COX-2 inhibitors - AEs

A

increased thrombosis risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Acetaminophen - MOA

A

reversibly binds COX, mostly in CNS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Acetaminophen - clinical use

A

antipyretic and analgesic (NOT anti-inflammatory)use to avoid Reye’s in kids w/ viral infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Acetaminophen - AEs

A

hepatic necrosis (glutathione depletion in liver)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Bisphosphonates - common one

A

Alendronate and other -dronates

17
Q

Bisphosphonates - MOA

A

binds hydroxyapatite in bone ->inhibits osteoclast activity

18
Q

Bisphosphonates - clinical use

A

osteoporosis, hypercalcemia, Paget’s disease

19
Q

Bisphosphonates - AEs

A

corrosive esophagitis, osteonecrosis of jaw

20
Q

Chronic gout treatment

A

allopurinol, febuxostat

21
Q

Acute gout- best NSAIDS

A

naproxen, indomethacin

22
Q

TNF-alpha inhibitors - common ones

A

EtanerceptInfliximab, adalimumab

23
Q

TNF-alpha - AEs

A

increased risk of infectionreactivation of TB, especially (prevents macrophage activation)

24
Q

Etanercept - MOA

A

fusion protein (decoy receptor)

25
Q

Etanercept - clinical use

A

RA, psoriasis, ankylosing spondylitis

26
Q

Infliximab/adalimumab - MOA

A

anti-TNF-alpha monoclonal antibody

27
Q

Infliximab/adalimumab - clincal use

A

Crohn’s, RA, ankylosing spondylitis, psoriasis

28
Q

Other chronic gout drug and MOA

A

Probenecid - inhibits uric acid reabsorption at PCT

Musculoskeletal (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions