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Immunology Introduction FA > Pathology - oncogenes and tumor suppressors > Flashcards

Pathology - oncogenes and tumor suppressors Flashcards

path intro

1
Q

oncogene: abl
assoc tumor?
gene product?

A

CML

tyr kinase

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2
Q

oncogene: c-myc
assoc tumor?
gene product?

A

burkitts lymphoma

TF

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3
Q

oncogene: bcl-2
assoc tumor?
gene product?

A

follic and undiff lymphoma

ANTI-APOPTOTIC MOLECULE*

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4
Q

oncogene: HER2/neu (c-erbB2)
assoc tumor?
gene product?

A

breast, ovarian, and gastric carcinoma

tyr kinase

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5
Q

oncogene: ras
assoc tumor?
gene product?

A

colon carcinoma

GTPase

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6
Q

oncogene: L-myc
assoc tumor?
gene product?

A

lung tumor

TF

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7
Q

oncogene: N-myc
assoc tumor?
gene product?

A

Neuroblastoma

TF

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8
Q

oncogene: ret
assoc tumor?
gene product?

A

multiple endocrine neoplasia (MEN) types 2A and 2B

tyr kinase

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9
Q

oncogene: c-kit
assoc tumor?
gene product?

A

GI stromal tumor

Cytokine rec

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10
Q

oncogene def?

A

gain of function –> INCREASED cancer risk

need to damage ONLY ONE allele*

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11
Q

tumor suppressor gene def?

A

loss of function —> INCREASED cancer risk

BOTH alleles must be lost for expression of dz

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12
Q

tumor suppressor: Rb
assoc tumor?
gene produce?

A

RetinoBlastoma, osteosarcoma

inhib E2F; block G1–>S

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13
Q

tumor supp: p53
assoc tumor?
gene produce?

A

most human cancers, Li-Fraumeni syn

TF for p21, block G1–>S

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14
Q

tumor supp: BRCA1
assoc tumor?
gene produce?

A

Breast and ovarian cancer

DNA repair protin

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15
Q

tumor supp: BRCA2
assoc tumor?
gene produce?

A

breast and ovarian cancer

DNA repair protein

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16
Q

tumor supp: p16
assoc tumor?
gene produce?

A

melanoma

-

17
Q

tumor supp: BRAF
assoc tumor?
gene produce?

A

melanoma

B-raf

18
Q

tumor supp: APC
assoc tumor?
gene produce?

A 
colorectal cancer (assoc with FAP)
-
19
Q

tumor supp: WT1
assoc tumor?
gene produce?

A

Wilm’s Tumor (nephroblastoma)

-

20
Q

tumor supp: NF1
assoc tumor?
gene produce?

A

NeuroFibromatosis 1

RAS GTPase activating protein (RAS-GAP)

21
Q

tumor supp: NF2
assoc tumor?
gene produce?

A

NeuroFibromatosis 2

Merlin (schwannomin) protein

22
Q

tumor supp: DPC4
assoc tumor?
gene produce?

A

Pancreatic Cancer

DPC - Deleted in Pancreatic Cancer

23
Q

tumor supp: DCC
assoc tumor?
gene produce?

A

colon cancer

DCC - Deleted in Colon Cancer

Immunology Introduction FA (4 decks)

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