path - chemical carcinogen + paraneoplastic syndromes Flashcards
toxin: aflatoxin (aspergillus)
organ?
impact?
liver
hepatocellular carcinoma
toxin: vinyl chloride
organ?
impact?
liver
angiosarcoma
toxin: carbon tetrachloride
organ?
impact?
liver
centrilobular necrosis, fatty change
toxin: nitrosamines (smoked foods)
organ?
impact?
stomach
gastric cancer
toxin: cigarette smoke
organ?
impact?
larynx - SQC lung - SQC and small cell carc kidney - renal cell card bladder - transitional cell card panc - panc adenocarcinoma
toxin: asbestos
organ?
impact?
lung
bronchogenic carc > mesothelioma
toxin: arsenic
organ?
impact?
skin - SQC
liver - angiosarcoma
toxin: naphthalene (aniline) dyes
organ?
impact?
bladder
transitional cell carcinoma
toxin: akylating agents
organ?
impact?
blood
leukemia
ACTH or ACTH-like peptide
effect?
neoplasm?
cushing syn
small cell lung carc
ADH
effect?
neoplasm?
SIADH
small cell lung card and intracranial neoplasm
PTHrP
effect?
neoplasm?
hypercalcemia
SQC, renal cell, breast cancer
1,25-(OH)2D3 (calcitriol)
effect?
neoplasm?
hypercalcemia
hodgkin’s lymphoma, some non-hodgkins lymphoma
Erythropoietin
effect?
neoplasm?
polycythemia
renal cell carcinoma, hemangioblastoma, hepatocellular carc, pheochromocytoma
Antibodies against presynaptic Ca2+ ch at NMJ
effect?
neoplasm?
Lambert - Eaton Syn (musc weakness)
small celll lung carcinoma
