Pathology of Viral Infections

Question 1

[Incubation Period] Dengue

Answer 1

3-14 days (ave 4-7)

Question 2

[Diagnosis] Dengue

Answer 2

isolating the virus, detecting viral antigen or RNA in serum or tissues, or detecting specific antibodies in the patient’s serum

Question 3

[Symptoms] Dengue

Answer 3

acute onset of fever accompanied by frontal headache,
retro-orbital pain, body aches, nausea and vomiting,
joint pains, weakness, and rash.

Question 4

What disease is caused by Rhinovirus?

Answer 4

Respiratory Diseases

Question 5

[Incubation Period] Rhinovirus

Answer 5

1-2 Days

Question 6

[Diagnosis] Rhinovirus infection

Answer 6

culture from washings or nasal

secretions

Question 7

[Symptoms] Rhinovirus infection

Answer 7

rhinorrhea, sneezing, and nasal congestion,may have sore throat,

but mild or absent constitutional s/s like body malaise and headache; fever unusual

Question 8

[Clinical Management] Rhinovirus infection

Answer 8

not necessary, since self-limited

Question 9

[Incubation Period]

Respiratory Syncytial Virus Pneumovirus

Answer 9

4-6 days

Question 10

[Diagnosis]Respiratory Syncytial Virus Pneumovirus

Answer 10

isolation of RSV from respiratory secretions,
including sputum, throat swab, and nasopharyngeal
washes

Question 11

[Symptoms] Respiratory Syncytial Virus Pneumovirus

Answer 11

begins with rhinorrhea, low grade fever, cough and

wheezing, mild systemic symptoms

Question 12

[Management] Respiratory Syncytial Virus Pneumovirus

Answer 12

respiratory therapy, including hydration, suctioning of

secretions, administration of humidified O2, antibronchospastic agents, even ventilatory assistance

Question 13

[Symptoms] Mumps

Answer 13

Parotitis, orchitis, encephalitis

Question 14

[Viral Agent] Measles

Answer 14

Rubeola virus

Question 15

[Diagnosis] Measles

Answer 15

mononuclear cell infiltration and multinucleate giant cells.xlymphoid hyperplasia prominent in cervical and
mesenteric lymph nodes, spleen appendix

Question 16

[Disease] rash – blotchy, reddish-brown – produced by dilatedskin vessels, edema, and a moderate, nonspecific, mononuclear perivascular infiltrate (a vasculitis of small blood vessels)

Answer 16

Measles

Question 17

[Prodromal Period] Rabies

Answer 17

2-10 days

Question 18

[Disease] transient viremia and fever, spinal or brainstem bulbar

Answer 18

Polio

Question 19

[Disease] characterized by rash, arthralgias, and transient interruption in erythrocyte production

Answer 19

Parvovirus B19

Question 20

[Disease] general malaise, chills, fever, headache S/s of CNS dysfunction like anxiety, agitation, paralysis, episodes of delirium, “furious” and “dumb”

Answer 20

Rabies

Question 21

[Clinical Management] Polio

Answer 21

anti-virus antibodies control the disease in most cases, vaccine

Question 22

[Incubation period] Parvovirus

Answer 22

4-14 days

Question 23

[Incubation Period] Small Pox

Answer 23

12-14 days

Question 24

[Incubation Period] Hand, Foot and Mouth Disease

Answer 24

4-7 days

Question 25

Dengue Virus a. Flaviviridae b. Parvoviridae c. Lyssaviridae d. Papovavridae e. Paramyxoviridae

Answer 25

A

Question 26

HPV a. Picornaviridae b. Parvoviridae c. Lyssaviridae d. Papovavridae e. Paramyxoviridae

Answer 26

D

Question 27

Rhinovirus a. Picornaviridae b. Parvoviridae c. Lyssaviridae d. Papovavridae e. Paramyxoviridae

Answer 27

A

Question 28

Coxsackie Virus a. Picornaviridae b. Parvoviridae c. Lyssaviridae d. Papovavridae e. Paramyxoviridae

Answer 28

A

Question 29

Rabies a. Picornaviridae b. Parvoviridae c. Lyssaviridae d. Papovavridae e. Paramyxoviridae

Answer 29

C

Question 30

Mumps Virus a. Picornaviridae b. Parvoviridae c. Lyssaviridae d. Papovavridae e. Paramyxoviridae

Answer 30

E

Question 31

Respiratory Syncitial Virus/Pneumovirus a. Picornaviridae b. Parvoviridae c. Lyssaviridae d. Papovavridae e. Paramyxoviridae

Answer 31

E

Question 32

[Duration] | Dengue acute febrile period

Answer 32

2-10 days; negative serology; still mounting antibody response

Question 33

Platelet count in DHF

Answer 33

100,000/mm3, note normal: 150,000/mm3

Question 34

[Identify] | Small, non-enveloped ssRNA, acid labile and grows best at 33-34degC

Answer 34

Rhinovirus

Question 35

Which antibody is protective against Respiratory syncitial virus?

Answer 35

Nasal IgA neutralizing antibody

Question 36

ssRNA enveloped Paramyxiviridae with large surface glycoprotein with both hemagglutinin and neuraminidase activity

Answer 36

Mumps virus

Question 37

[Viral pathogen] | German measles

Answer 37

Rubella

Question 38

[Viral pathogen] | Chicken pox, shingles

Answer 38

Varicella, varicella-zoster

Question 39

Rubella a. Picornaviridae b. Parvoviridae c. Lyssaviridae d. Papovavridae e. Paramyxoviridae

Answer 39

E

Question 40

Protection against Rubella is via a. cell mediated immunity b. antibody mediated immunity

Answer 40

B

Question 41

ulcerated mucosal lesions in the oral cavity near the opening of the stensen's duct

Answer 41

Koplik spots

Question 42

Measles giant cells a.k.a

Answer 42

Warthin-Finkeldey cells

Question 43

Round eosinophilic cytoplasmic | inclusions measuring 1-7 μm are pathognomonic of rabies

Answer 43

negri bodies

Question 44

What is the preferential site for negri body formation

Answer 44

hippocampal neurons

Question 45

Polio __ attenuated vaccine can in some cases | revert back to wild type (most pathogenic)

Answer 45

Polio 3 attenuated vaccine can in some cases | revert back to wild type (most pathogenic)

Question 46

Which Polio strain is most virulent?

Answer 46

Polio1

Question 47

killed, formalin-fixed polio vaccine a. Sabin b. Salk

Answer 47

B

Question 48

live, attnuated polio vaccine a. Sabin b. Salk

Answer 48

A

Question 49

which polio vaccine is less immunogenic? a. Sabin b. Salk

Answer 49

B

Question 50

Neuronophagia is a typical manifestation of a. rabies b. polio c. Herpes d. Chicken pox

Answer 50

B

Question 51

``` The ff are sexually transmitted except a. HPV 16, 18 b. Molluscum contangiosum c. Herpes d. HIV e. AOTA F. NOTA ```

Answer 51

F

Question 52

[Viral pathogen] | Infectious mononucleosis

Answer 52

Epstein Barr Virus

Question 53

[Viral Pathogen] | Kaposi Sarcoma

Answer 53

Herpes Simplex 8

Question 54

[Disease that it causes] | HPV Types 6,10, 11, 40-45

Answer 54

anogenital warts/ condyloma acuminata

Question 55

[Disease that it causes] | HPV Types 16, 18, 31

Answer 55

squamous cell dysplacias and squamous cell carcinomas of the female genital tract; 16,18 most common 16 most common in the Philippines

Question 56

Cytopathic effect of HPV infected cells;when squamous cells become large with shrunken nuclei enveloped in large cytoplasmic vacuoles

Answer 56

Koilocytosis

Question 57

verrucae vulgares a.k.a

Answer 57

common warts

Question 58

verrucae planae a.k.a

Answer 58

flat warts

Question 59

condyloma acuminata a.k.a

Answer 59

anogenital warts

Question 60

papular lesions located on the folds of moist intertriginous areas that coalesce to form flat, wartlike lesions, especially around the genitalia and anuslesions associated with secondary syphilis

Answer 60

condyloma lata