Pathology of Small Bowel Flashcards
Is bowel ischemia more likely to be acute or chronic?
Acute
Which part of the bowel wall is most likely to be effected by hypoxia?
Mucosa
What is Meckel’s Diverticulum the result of?
Incomplete regression of vitello-intestinal duct
What type of mucosa may Meckel’s Diverticulum contain?
Heterotopic gastric mucosa
Which are more common in the small bowel, primary or secondary tumours?
Secondary
What types of primary tumours are there in the small bowel?
Lymphomas, carcinoid tumours, carcinomas
What is the rarest type of primary tumour and what colour is it?
Carcinoid, yellow
What must acute inflammation in appendicitis involve?
the muscle coat
What happens histologically in appendicitis?
Mucosal ulcertation, mural inflammation, pus in lumen
What invade the vessel wall in appendicitis?
Neutrophils
What is Coeliac Disease caused by?
Caused by an abnormal reaction to a constituent of wheat flour, gluten, which damages enterocytes and reduces absorbtive capacity
What gene serotype is Coeliac Disease associated with?
HLA-B8
What are childhood diabetes and dermatitis herpetiformis associated with?
Coeliac Disease
In Coeliac disease, why is there an increasing loss of enterocytes?
Due to IEL mediated damage
What does this loss of enterocytes lead to?
This leads to loss of villous structure, loss of surface area,
a reduction in absorbtion and a flat duodenal mucosa
