Pathology of Mouth and Esophagus

Question 1

Answer 1

HSV infection of epithelial cells

multinucleation and nuclear inclusion

Question 2

Answer 2

nuclear owl’s eye inclusions in CMV - infects endothelial/mesenchymal cells

Question 3

candida characteristics

Answer 3

budding yeast, pseudohyphae

Question 4

aspergillus

Answer 4

hyphae, 45 degree branching

Question 5

mucormycosis

Answer 5

hyphae, 90 degree branching

Question 6

Answer 6

pyogenic granuloma

Question 7

characteristics of hairy leukoplakia

Answer 7

hyperkeratosis, acanthosis, “Balloon” cells

Question 8

which is more worrisome - leukoplakia or erythroplakia

Answer 8

erythroplakia - higher risk of progression to malignancy

Question 9

most common type of oral cavity cancer

Answer 9

squamous cell carcinoma

assoc w/ smoking, alcohol, HPV

Question 10

salivary gland tumors

Answer 10

benign: pleomorphic adenoma, warthin tumor
malignant: mucoepidermoid carcinoma, acinic cell carcinoma, adenoid cystic carcinoma

Question 11

2 types of esophageal rings

Answer 11

“A” ring: lower esophagus - above GE junction (squamous mucosa)

B-ring (Schatzki’s): at GEJ (glandular mucosa)

Question 12

Mallory weiss tear

Answer 12

laceration @ GEJ

forceful vomiting

Question 13

Boerhaave syndrome

Answer 13

eat to much + vomit –> esophageal rupture and death

Question 14

criteria for Barrett’s esophagus

Answer 14

• endoscopic evidence of columnar epithelium in distal esophages
• intestinal metaplasia (goblet cells on mucosal biospy)

Question 15

barrett’s puts you at risk for

Answer 15

esophageal adenocarcinoma

Question 16

most common type of esophageal cancer

Answer 16

squamous cell carcinoma

but adenocarcinoma incidence is rising