Pathology of Gastric Diseases

Question 1

what defines epithelial neoplasm

Answer 1

intermediate filaments

Question 2

autoimmune gastritis

Answer 2

antibody-mediated destruction of parietal cell

assoc w/ pernicious anemia

cancer risk

Question 3

Menetrier Disease

Answer 3

foveolar hyperplasia

protein losing gastropathy

Question 4

Answer 4

signet ring cell carcinoma

Question 5

what is the most important prognostic variable in gastric adenocarcinoma?

Answer 5

depth of invasion: does it penetrate the muscularis propria

Question 6

sites for distant metastases in gastric carcinoma

Answer 6

Virchow’s node: L supraclavicular

Krukenberg tumor: ovarian metastasis, usually bilateral

Question 7

staging of Gastrointestinal stromal tumor

Answer 7

depends on size and number of mitoses

TNF staging doesn’t work

Question 8

types of mucosa in different parts of the stomach

Answer 8

• cardia: mucous secreting epithelium
• fundus/body: oxyntic epithelium (acid proucing)
• pylorus/antrum: mucous secreting

Question 9

two etiologies of chronic gastritis

Answer 9

1. H. pylori: usually in antrum, assoc w/ MALT lymphoma
2. Autoimmune gastritis

Question 10

two types of gastric carcinoma

Answer 10

1. intestinal type: arises from dysplasia
2. diffuse type: signet ring, leather bottle stomach