Pathology of Endocrine 1&2

Question 1

What are the 3 main adrenal cortical hyperfunction syndromes?

Answer 1

1) Cushings syndrome
2) Conn’s syndrome
3) Adrenogenital syndrome

Question 2

What are the different causes of Cushings syndrome?

Answer 2

1) Iatrogenic - steroids
2) ACTH dependent - pituitary adenoma (cushings disease)
3) ACTH independent - functioning adrenal adenoma

Question 3

What are the causes of Conn’s syndrome?

Answer 3

1) Bilateral idiopathic hyperplasia
2) Functioning adrenal adenoma

Question 4

What is the primary adrenal insufficiency disorder?

Answer 4

Addison’s disease

Question 5

Metastatic carcinomas of the Adrenal cortex are most likely to have metastasised from where?

Answer 5

1) Lung
2) Breast

Question 6

What is a tumour of the adrenal medulla called?

Answer 6

Phaeochromocytoma (secretes catecholamines - leading to hypertension)

Question 7

What is MEN1?

Answer 7

A tumour suppressor gene mutation- defects the menin protein growth

Parathyroid

Panreas and duodenum

Pituitary