Pathology Intracellular Accumulation

Question 1

What is the difference between endogenous and exogenous cellular inclusions ?

Answer 1

Endogenous - increase in subatsnce than naturally occur in the body

Exogenous - increase in substance which is not natural

Question 2

What causes lipid Accumulation ?

Answer 2

Increase in triglyceride
Cannot convert it
Decrease fatty acid oxidation
Decrease apoprotien

Question 3

What are the types of protein Accumulation ?

Answer 3

Mallory body
Councilman body
Russell’s body

Question 4

What causes Mallory body ?

Answer 4

Eosinophollic masses in liver
Alcoholics
Pre Keratin filaments Accumulation

Question 5

What causes councilman body ?

Answer 5

Apoptotic Eosinophollic body
Acutue viral hepatitis

Question 6

What causes Brussels body ?

Answer 6

Spherical hyaline masses within plasma cells
Chronic Inflammation

Question 7

What are the types of pigment Accumulation ?

Answer 7

Lipofusion
Hemosiderin
Bilurubin
Hemochromatosis

Question 8

How do you differentiate between Hemosiderin and lipofusion ?

Answer 8

Lipofusion -
Brown residues around lysosomes

Hemosiderin -
Golden brown/yellow in strands

Question 9

What causes golden diabetes ?

Answer 9

Hemochromatosis
Increased intestinal absorption of iron and Accumulation in parenchymal cells