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Block 4 New > Pathology Cell Injury > Flashcards

Pathology Cell Injury Flashcards

1
Q

What are the irreversible damage changes in nucleus ?

A

Pyknosis (nucles shrinks) (incrse in basophils)

Karyorrhexis (nucles fragments)

Karyolysis (basophil fades, nucles dies)

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2
Q

What are the two important characteristics of reversible cell injury ?

A

Decreased ATP
Increasesd Calcium

Cell swelling
Fatty exchange

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3
Q

CCL4 CAUSES ?

A

IR CELL DAMAGE IN SMOOTH ER

LIPID ACCUMULATION

DEGRADATION OF LIPIDS TO ORGANIC PEROXIDE

IN DRY CLEANERS

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4
Q

What is the difference between apoptosis and necrosis ?

A

Apoptosis - natural ce death
Necrosis- pathological cell death

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5
Q

Which type of cell death causes adjacent inflammation ?

A

Necrosis

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6
Q

In which cell death is the plasma membrane intact and not leaked out ?

A

Apoptosis

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7
Q

What are the two pathways of apoptosis ?

A

INTRISIC (mitochondrial)
Extrinsic (death receptors)

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8
Q

What causes activation of intrinsic pathway ?

A

Lack of growth factors and tissue Dange
P53 and BCL-2

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9
Q

What causes activation of Extrinsic pathway ?

A

Extrinsic death signals
TNF-APLHA,

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10
Q

What is the general pathway of apoptosis ?

A

Stimulus
Activator of initiator caspase
Activation of executior caspase
Apoptosis

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11
Q

What are the appearance of apoptosis ?

A

Cell shrinkage
Blebbing
Chromatin condensation
Phagocytosis of apoptic body

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12
Q

What are the reasons of pathological apoptosis ?

A

Chemicals, pathogens
COUNCILMAN BODIES

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13
Q

What is necrosis ?

A

Unprogrammed cell death
Usually with inflammation

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14
Q

What are the types of necrosis ?

CLC
FGF

A

COAGULATIVE
LIQUEFACTIVE
CASEOUS
FAT
GAMGRENOUS
FIBRINOID

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15
Q

What are the features of COAGULATIVE necrosis ?

A

Solid organs (except brain)
No nuclei
Inflammatory infiltrate present
FIRM TEXTURE

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16
Q

What are the features of liquefaction necrosis ?

A

NO CELL BOUNDRIES
NO NUCLEI
PUS
BRAIN

17
Q

What are the features of CASEOUS ?

A

Cell debris but no cell boundaries
Eosinophollic
Lungs
Point between COAGULATIVE and LIQUEFACTIVE

OY IN TB

18
Q

What are the features of fat necrosis ?

A

PANCREAS AND PERITONIAL CAVITY
BREASTS

SHADOWY ISLAND OF NECROTIC FAT CELLS
FAT MIX WITH CALCIUM, CHALK LIKE SUBSTANCES.

19
Q

What are the features of GAMGRENOUS NECROSIS ?

A

BLACK
NO BLOOD SUPPPLY
WET- BACTRIAL INFECTIN
DRY - MUMMIFIED TISSUE

APPENDAGES

WET- PUS

20
Q

What are the features of FIBRINOID NECROSIS ?

A

NEAR BLOOD VESSELS

BRIGHT PINK APPEARENCE

ANTIGENS AND ANTIBODIES DEPOSITED IN BLOOD VESSELS

Block 4 New (9 decks)

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