Pathology Definitions Flashcards
81MASTITIS
Inflammation of the breast.
18ATYPIA
Structural abnormality in a cell due to reactive or neoplastic processes
21BIOPSY
Process involving extraction of sample cells or tissues for examination to determine the presence or extent of a disease.
30CYST
An abnormal closed epithelium-lined cavity in the body, containing liquid or semisolid material.
98 TOPHUS IS CHARACTERISTIC FOR:
Gout
5AGENESIS
Complete absence of an organ or is anlage.
125MOST COMMON LOCALIZATION OF EWING’S SARCOMA
Middle regionof long tubular bones.
4ADHESION
Adhesions are fibrous bands of scar tissue that form between internal organs and tissues, joining them together abnormally.
41EMPHYSEMA
Permanent enlargement of the air spaces distal to the terminal bronchioles, accompanied by destruction of their walls without significant fibrosis.
154VIRCHOW’S LYMPH NODE
Metastatic supraclavicular lymph node. The most common primary tumor is gastric adenocarcinoma.
10APOPTOSIS
Pathway of cell death in which cells activate enzymes that degrade the cells’ own nuclear DNA and nuclear and cytoplasmic proteins.
158HIRSCHPRUNG’S DISEASE
Bowel motility disorder caused by the abscence of ganglion cells in the myenteric plexus.
101PUSTULE
Discrete, pus-filled, raised lesion.
184MOST COMMON BENIGN TUMOR OF THE BREAST
Fibroadenoma.
15ATHEROSCLEROSIS
Characterized by intimal lesions called atheromas (or atheromatous or atherosclerotic plaques) that impinge on the vascular lumen and can rupture to cause sudden occlusion.
161CIRRHOSIS
Diffuse transformation of the liver into regenerative parenchymal nodules surrounded by fibrous bands, end stage of chronic liver disease.
183PROGNOSTIC AND PREDICTIVE FACTORS OF BREAST CARCINOMA
Histologic type, grade, stageEstrogen-, progesteron-, and Her2 receptor status, Ki-67 proliferation index
24CARCINOMA
Malignant neoplasms of epithelial cells.
82MELANOMA
Malignant tumor of melanocytes.
20BALANITIS
Local inflammation of the glans penis.
75INVOLUTION
Reduction of volume of an organ or tissue (similarly to atrophy) due to physiological processes (e.g. thymus)
195 BRESLOW’S DEPTH
Thickness (mm) of skin melanoma measured from the granular layer of the epidermis.
153HEPATORENAL SYNDROME
Renal failure in patients with severe liver disease in the absence of morphological change of the kidneys.
44ENDOPHYTIC
Tending to grow inward into tissues in fingerlike projections from a superficial site of origin —used for tumors
70INFLAMMATION, acute serous
Initial, rapid response to infections and tissue damage marked by exudation of cell-poor fluid.
LIST THE FEATURES OF CROHN’S DISEASE!
Inflammatory bowel disease affecting the whole GI tract Segmental inflammation Inflammation in all layers of the bowel wall, with granuloma formation and deep fissural ulcers Fissures and fistules common Thickening of the bowel wall, stricture of the lumen Extraintestinal symptoms
99PSEUDOCYST
Liquefied areas of necrotic tissue become walled off by fibrous tissue to form a cystic space, lacking an epithelial lining.
133RUPTURE OF THE HEART FOLLOWING A MYOCARDIAL INFARCTION OCCURS MOST LIKELY:
2-10 days after infarction.
12ARTERITIS
Arterial wall inflammation.
55HEMATOMA
Hemorrhage accumulating within a tissue.
31DEGENERATION
Gradual deterioration of specific tissues, cells, or organs with corresponding impairment or loss of function.
60HYALINE
A clear, eosinophilic, homogeneous substance occurring in cellular degeneration.
22TROUSSEAU SIGN
Migratory thrombophlebitis occurring in tumor patients. It is attributable to the elaboration of platelet-aggregating factors and pro-coagulants from the tumorcells.
90PETECHIAE
Minute (1 to 2 mm in diameter) hemorrhages into skin, mucous membranes, or serosal surfaces.
48EXUDATE
Protein-rich fluid accumulation
152CAROLI DISEASE
Congenital disorder comprising of multifocal cystic dilatation of segmental intrahepatic bile ducts.
ASCITES
Extravascular fluid collection (effusion) in the peritoneal cavity.
180MEIGS’ SYNDROME
Ovarial fibrothecoma associated hydrothorax.
57HEMOTHORAX
Hemorrhage within the pleural cavity.
49FIBROSIS
Excessive deposition of collagen and other ECM components in a tissue.
79LITHIASIS
Formation of calculi (stones).
53GRANULOMA
Aggregates of activated macrophages with scattered lymphocytes.
2ADENOCARCINOMA
Malignant tumor of glandular epithelium.
51GRADE
Level of malignancy based on the cytological differentiation of tumor cells and the number of mitoses within the tumor.
89PAPILLOMA
Benign epithelial neoplasms, growing on any surface, that produce microscopic or macroscopic fingerlike fronds.
85NECROSIS
Form of cell death in which cellular membranes fall apart, and cellular enzymes leak out and ultimately digest the cell.
168HASHIMOTO’S DISEASE
Autoimmune lymphocytic thyroiditis.
166PATHOGENESIS OF GRAVES’ DISEASE
Thyroid stimulating anti-TSH receptor autoantibodies.
175HISTOLOGICAL TYPES OF GERM CELL NEOPLASMS OF THE TESTIS
Seminoma, embryonal carcinoma, yolk sac tumor, teratoma, choriocarcinoma, spermatocytic tumor.
65INFARCTION, anemic
Area of ischemic necrosis caused by occlusion of the vascular supply to the affected tissue.
155LIST THE FEATURES OF ULCERATIVE COLITIS
!Inflammatory bowel disease, beginning in the rectum, affecting only the colon Continous inflammation affecting only the mucosa and submucosa with broad based ulcers Bowel wall becomes thin Extraintestinal symptoms
37ECTASIA
Any local dilation of a structure.
11ARTERIOSCLEROSIS
Hardening of the arteries, arterial wall thickening and loss of elasticity.
140ETIOLOGICAL FACTOR OF MESOTHELIOMAS:
Asbestos.
191WHERE DOES OSTEOSARCOMA ARISE MOST COMMONLY?
Metaphysis of long cortical bones, mainly distal femur and proximal tibia
136EXAMPLESFOR BENIGN AND MALIGNANT SALIVARY GLAND TUMORS!
Benign: pleomorphic adenoma, basal cell adenoma, Whartin tumorMucoepidermoid carcinoma, aciniccell carcinoma, adenoid cystic carcinoma, myoepithelial carcinoma
107REMISSION
Partial or complete disappearance of a chronic or a malignant disease.
193SCHWANNOMA
Tumor of the peripheral nerves
164HISTOLOGICAL AND CLINICO-PATHOLOGICAL FEATURES OF PAPILLARY CARCINOMA OF THE THYROID:
Grooves, intranuclear cytoplasmic inclusions, crowding of nuclei, ground-glass (Orphan Annie) nuclei, Psammoma bodies, papillary and/or follicular structures. It rarely gives metastasis, if yes, lymphogenic metastasis to the cervical lymph nodes.
134FORMS OF STERILE (NON-INFECTIOUS) ENDOCARDITIS:
Marantic endocarditis, endocarditis associated with carcinoid-syndrome
71INFLAMMATION, chronic active
Pattern of chronic mucosal inflammation mixed with acute inflammation of the glands.
35DYSPLASIA
Disorderly proliferation of the epithelium recognized by a loss in the uniformity of individual cells and in their architectural orientation.
98PROCTITIS
Inflammation of the rectum
112SHOCK
A state in which diminished cardiac output or reduced effective circulating blood volume impairs tissue perfusion and leads to cellular hypoxia.
105REGENERATION
Replacement of damaged tissue components and essentially return to a normal state.
121ULCER
Local defect, or excavation, of the surface of an organ or tissue that is produced by the sloughing (shedding) of inflamed necrotic tissue.
141WHICH LUNG TUMOR TYPE PRODUCES COMMONLY HORMONES?
Small cell carcinoma.
86NEOPLASM
Tissue growth due to abnormal and uncontrolled cell proliferation.
33DESMOPLASIA
Tumor induced stromal reaction characterized by collagen rich connective tissue.
80LYMPHOMA
Malignant tumor of the lymphoid tissue.
201GASTROSCHISISA
birth defect in which abdominal viscera protrude through the incomplete abdominal wall.
96PNEUMOTHORAX
Air in the thoracic cavity.
171WHICH TWO CARCINOMA TYPES INFILTRATE COMMONLY TO MAJOR VEINS?
Hepatocellular carcinoma, clear cell carcinoma of the kidney.
145TECHNIC OF CERVICAL CANCER SCREENING:
Exfoliative cytology.
72INFLAMMATION, chronic non-specific
Prolonged host response (weeks or months) to persistent stimuli that may follow unresolved acute inflammation or be chronic from the onset (cells: lymphocytes, plasma cells).
174PRIMARY LOCALIZATION OF LYMPHOGENOUS METASTASES IN MALIGNANT TESTICULAR TUMORS:
Paraaortic lymph nodes.
138PANCOAST TUMOR
Locally disseminated, malignant tumor in the apex of the lung.
63HYPERPLASIA
Hyperplasia is an increase in the number of cells in an organ that stems from increased proliferation, either of differentiated cells or, in some instances, less differentiated progenitor cells.
83METAPLASIA
Change in which one adult cell type (epithelial or mesenchymal) is replaced by another adult cell type.
9APLASIA
Incomplete development of an organ or its anlage.