Pathology and Medicine Flashcards
What does acute mean?
What does chronic mean?
A rapid onset disease, (but not always followed by rapid resolution)
May follow an acute initial episode and have a prolonged course lasting months or years
What do these prefixes mean?
- ana
- dys
- hyper
- hypo
- meta
- neo
Absence
Disordered
Excess over normal
Deficiency below normal
Change from one state to another
New
What do these suffixes mean?
- itis
- oma
- osis
- oid
- plasia
- opathy
Inflammatory process
Tumour
Abnormal increase
Bearing resemblance to
Disorder of growth
Abnormal state lacking specific characteristics
What are disease classifications based on?
Causes (aetiology) and underlying mechanisms (pathogenesis)
Classification of a disease is commonly based on?
A) The on-set of a disease
B) The reversibility of a disease
C) The name of the doctor who discovered it
D) The mechanism of a disease
E) None of the above
D)
What is a congenital disease?
What is the other type of disease classification?
Initiated before or during birth, may not manifest until adult life. Can be genetic or non-genetic
Acquired
What is the pathogenesis of a disease?
The mechanism through which the aetiology (cause) operates to produce the pathological and clinical manifestations
What is a symptom?
What is a sign?
What the patient feels/ complains about
What the doctor is looking for
What is a syndrome?
An aggregate of signs and symptoms or a combination of lesions without which the disease cannot be recognised or diagnosed
What is morbidity?
The disease state of an individual, or the incidence of illness in a population - the proportion of patients with a particular disease during a given year per given unit of population
What is mortality?
The probability death will be the end result of that disease
What is prevalence?
The total number of cases of a given disease in a specified population at a designated time (morbidity and incidence refer to new cases)
What is a prospective study?
What is a retrospective study?
What are cross-sectional studies?
Subjects are followed over time
Looking back over a period of time
Prevalence between different populations at a particular time
What happens if cytosolic calcium levels increase?
It can cause irreversible damage and cells death
What are the four types of necrosis? Describe them.
Coagulative necrosis - most common form, occurs in all tissues except brain
Liquefactive/colliquative necrosis - affects cells in the CNS, complete digestion of dead cells results in tansformation of tissue into a liquid viscous mass
Caseous necrosis - found in tuberculosis infection, tissue architecture is completely obliterated
Fat necrosis - occurs during pancreatitis, result of rereleased active pancreatic lipases
What are some of the characteristics of apoptotic cells? (There are 6)
Degradation of the cytoskeletal framework
Fragmentation of DNA
Loss of mitochondrial function
Nucleus shrinks (pyknosis) and fragmentation (karyorrhexis)
Cell shrinks but retains intact plasma membrane (which induces phagocytosis)
Apoptotic bodies
Name three components/ processes involved in haemostasis.
Vascular wall
Platelets
The coagulation cascade
Name and briefly describe three predisposing factors of thrombosis.
Endothelial injury - exposure of underneath ECM, adhesion of platelets and release of tissue factor
Stasis or turbulence of blood flow - turbulence occurs in arteries and stasis occurs in veins
Blood hypercoagulability - in some individuals clotting factors are hyperactive
Name seven risk factors for thrombosis.
Prolonged bed rest or immobilisation - causes stasis
Myocardial infarction - activates clotting factors and releases TF
Atrial fibrillation - ventrical can’t pump enough blood causing stasis
Prosthetic cardiac valves - valves different shape so create turbulence
Tissue injury, surgery, fracture, burn - releases tissue factor
Cancer - tumours release TF and cytokines that promote coagulation
Increased age - reduced activity causes stasis
What are the common sites where thrombosis forms?
Coronary cerebral and femoral arteries
Venous thrombosis can cause pulmonary infarction true or false?
True
In reference to thrombosis what is an embolism?
Where part of the thrombus dislodges and travels to other parts in the vasculature
What are the usually consequences of arterial embolisms?
Infarction or gangrene
On examination of a heart after autopsy, a myocardial infarct can usually be recognised 2 hours after coronary artery occulsion, true or false?
False
How many litres of blood does the healthy 70kg adult male’s body contain?
5 litres
What are the four clinical signs of inflammation?
What is the 5th sign added by laesa?
Redness, swelling, heat and pain
Loss of function
What is a oedema?
An excess of watery fluid collecting in cavities or tissues of the body
What are the main phagocytic cells involved in acute inflammation?
Neutrophils
What is hyperplasia?
An increase in the number of cells in an organ or tissue (resulting in increased volume of the organ or tissue)
What is hypertrophy?
An increase in the size of cells due to synthesis of more structural components (can result in an increase in size of the organ)
What is atrophy?
The shrinkage (reduced size) of an organ or tissue from a decrease in cell size or number
What is anaplasia?
Lack of differentiation, a hallmark of malignant transformation
What is neoplasia?
The process of new growth
The two types of benign epithelial tumours are papillomas and adenoids, where are they found?
Papillomas - in skin
Adenomas - in glands
What are malignant epithelial tumours called?
What are malignant connective tissue tumours called?
Carcinomas
Sarcomas
What is dysplasia?
Disordered growth (loss in uniformity of individual cells)
What are the names of the four valves in the heart?
Pulmonary valve
Aortic valve
Tricuspid valve
Mitral valve
What side of the heart does systemic hypertension affect?
What side of the heart does pulmonary hypertension affect?
Causes left heart hypertrophy
Causes right heart hypertrophy
What is cardiomyopathy?
When should it be diagnosed?
A heart muscle disease of uncertain cause.
Only when all other causes of cardiac failure e.g. hypertension, ischemic heart disease etc have been excluded
Which of the following is a compensatory mechanism for cardiac dysfunction?
A) cardiac hypertrophy
B) release of noradrenaline
C) activation of the renin-angiotensin-aldosterone system
D) release of atrial natriuretic peptide
E) all of the above
Answer E
What are the diastolic and systolic pressures that indicate hypertension?
A diastolic pressure greater than 89mm Hg
A systolic pressure greater than 139mm Hg
What is the equation for blood pressure?
BP = Cardiac output X peripheral resistance
What is an aortic dissection?
When blood goes into the media to form a blood-filled channel within the aortic wall
Aortic desiccation, true or false?
A) is a complication of atherosclerosis
B) often commenses distal to the aortic arch
C) is associated with systemic hypertension
D) can occur in patients with inherited connective tissue disorders
E) is usually fatal
A) true B) false C) true D) true E) true
What is atherosclerosis characterised by?
Intimal lesions (atheromatous or fibrofatty plaques) which protrude into and obstruct vascular lumens
What on an ECG indicates a myocardial infarction?
What indicates a past myocardial infarction?
ST-elevation
A large q wave
What percentage of blood is made of plasma?
What percentage is composed of cells?
55%
40-45%
Where does hematopoesis occur in the first 6wks - 6months of life?
Where does it occur after 6 months?
Liver and spleen
Bone marrow
What is the precursor cell of erthrocytes called?
Reticulocyte
What are the three essential dietary constituents required for haematopoesis?
Iron
Vitamin B12
Folic acid
What is the most common cause of anemia?
Iron deficiency
What is megaloblastic anaemia characterised by?
What causes it?
Large immature red blood cells (megaloblasts)
Vitamin B12 and folate deficiencies or metabolism problems. Other defects of DNA synthesis