Pathology Flashcards
Acute inflammation - Definition
- Initial + transient series of tissue reactions to injury
2. Appendicitis
Hyperplasia - definition
- Increase in cell number by mitosis
2. Benign prostate hyperplasia
Granuloma - Definition
- Aggregate of epitheliod histocytes
2. Crohn’s disease
Disorders of development of growth - Classification
- Congenital = present at birth
- Genetic
a. Inherited = inherited genetic abnormality
(Familial adenomatous polyposis AD)
b. Spontaneous = spontaneous mutation - Non genetic - environmental = acquired by environmental factors (fetal alcohol syndrome)
Cells that can regenerate
- Hepatocytes
- Pneumocytes
- All blood cells
- Gut/skin epi
- Osteocytes
Cells that can’t regenerate
- Myocardial cells
2. Neurones
Acute inflammation - Outcomes
- Resolution (acute lobar pneumonia)
- Suppuration
- Organisation
- Progression to chronic inflammation
Malignant tumour
- Invasive
- Not all metastatic (basal cell carcinoma)
- Rapid growth - irregular border
- Don’t resemble parent cells
- pleomorphic nuclei (vary shape and size)
Adenoma
- Benign tumour of glandular/secretory epi
2. Prefix with cell type of origin
Screening programmes
- Cervical cancer
- Breast cancer
- Colorectal cancer
Carcinogen
- Environmental agent participating in causation of tumours
- Carcinogenic (malignant)
- Oncogenic (tumour)
- Act on DNA
- Eg asbestos
Lipoma
Benign tumour of adipocytes
Adenocarcinoma
- Malignant tumour of glandular epi
2. Coupled w name of tissue of origin
Carcinoma
- Malignant tumour of epi
2. Prefixed by name of epi cell type
Leiomyoma
Benign tumour of SM cells
Anaplastic
- Do not know origin
2. Anaplastic carcinoma of thyroid = v low survival rate
Inflammation
Local physiological response to tissue injury
Chronic inflammation - Causes
- Primary chronic inflammation
- Transplant rejection
- Progression from acute inflammation
- Recurrent episodes of acute inflammation
Virchow’s triangle
- Stasis of blood flow
- Endothelial injury
- Hyper coagulability
Arterial thrombosis - Treatment
- Anti-platelets (aspirin/clopidogrel)
Venous thrombosis - Treatment
- Anti-coagulants (warfarin/heparin)
New oral anticoagulant drugs
Sarcoma
Malignant neoplasm of CT
Carcinomas to bone
BRRRRRS
- Bronchus (lung)
- Breast
- Bridney
- Bryroid
- Brostate
Metastasis sequence of events
- Invasion - Erosion of tissue boundaries
- Intravasation - into lumen of vessels
- Evasion of host defence
- Adhere to endo
- Extravasation - to surrounding tissue
- Angiogenesis - own blood vessels
Atheromatous plaque constituents
- Central lipid core
- Fibrous cap
- Smooth M cells
- Lymphocytes
- Macrophages
Hypertrophy
An increase in size of tissue due to an increase in size of individual cell (w/out cell division)
Lymphoma
Malignant neoplasm of lymphoid cells
Melanoma
Malignant neoplasm of melanocytes
Benign CT/mesenchymal tumours
- Named after cell of origin
- Suffix = oma
- Neuroma = benign tumour of N