Pathology Flashcards
Connective tissues all have a common theme, which is…
They are inflammatory / autoantibody driven
Lupus antibodies are directed against
Structural components of DNA
Scleroderma antibodies are directed against which structures? (2)
- Anti-centromere
- Anti-telomere
ANA+ and anti-dsDNA+ suggests which disease?
SLE
Anti-Scl-70+ suggests which disease?
Scleroderma
CREST is AKA
Scleroderma
Vasculitis only ever affects the arterial vessels. True/false?
False - more commonly arterial but can affect all vessels
Giant Cell Arteritis has a defined cause. True/false?
False - unknown
Biopsies are always diagnostic for GCA
False - segmental and skip lesions present
A negative biopsy rules out GCA. True/false?
False
Fibrinoid necrosis of vessel is buzzword for
Polyarthritis nodosa
Wegner’s is a small/large vasculitis which is also known as….
Small vasculitis. AKA Granulomatosis with polyangiitis
Churg-Strauss is AKA
Eosinophilic granulomatosis
Most common cause of overproduction of gout
Idiopathic (Lysch-Nyham is rare)
What is the most common cause of gout?
Under-excretion
Urate secretion is reduced by which common cardiac / resp medication?
Thiazide diuretics
Paget’s disease is a condition of more/less bone which is normal/abnormal.
More bone which is abnormal.
RANK-L is associated with which condition?
Paget’s Disease
Osteomalacia in the young is termed
Rickets
Osgood-Schlatter’s affects which area and in which group?
Affects the patellar tendon at its tibial insertion, affects the sporty youth.
Chondromalacia patella is AKA
Runner’s Knee
GCA affects which artery?
Temporal arteries (may also involve ophthalmic and vertebral)
Does a negative biopsy rule out GCA?
No, skip lesions
Polyarteritis nodosa is a vasculitis of which vessel size?
Small to medium sized
Does polyarteritis involve the lungs?
No, characteristically spares
Polyarteritis nodosa typically affects which organ?
Kidney
Is polyarteritis nodosa ANCA positive/negative?
Negative
Which % of Polyarteritis Nodosa patients havee hepatitis B?
33%
Henloch-Schlein-Purpura is a vasculitis of which vessel size?
Small
Goodpasture’s Syndrome is a vasculitis of which vessel size?
Small
Are crystals from gout present after lab processing?
No, lost in formalin and residual amorphous eosinophilic debris
Psuedogout is caused by what
Calcium pyrophosphate
Psuedogout is often incidentally seen on which imaging modality?
X-ray
What are the 3 stages of Paget’s?
Osteolytic
Mixed
Burnt out
“Thick excess bone with abnormal reversal line in a mosaic pattern” indicates which disease?
Paget’s
Leontiasis ossea is indicative of which disease?
Paget’s (Lion’s Face)
Platybasia is indicative of which disease
Paget’s (spine abnormality)
Sabre tibia is indicative of which disease?
Paget’s
What’s a potentially serious complication of Paget’s Disease (cancer)?
Osteosarcoma
“Rickety rosary” is a sign for which disease
Osteomalacia
