Pathology

Question 1

Connective tissues all have a common theme, which is…

Answer 1

They are inflammatory / autoantibody driven

Question 2

Lupus antibodies are directed against

Answer 2

Structural components of DNA

Question 3

Scleroderma antibodies are directed against which structures? (2)

Answer 3

• Anti-centromere

- Anti-telomere

Question 4

ANA+ and anti-dsDNA+ suggests which disease?

Answer 4

SLE

Question 5

Anti-Scl-70+ suggests which disease?

Answer 5

Scleroderma

Question 6

CREST is AKA

Answer 6

Scleroderma

Question 7

Vasculitis only ever affects the arterial vessels. True/false?

Answer 7

False - more commonly arterial but can affect all vessels

Question 8

Giant Cell Arteritis has a defined cause. True/false?

Answer 8

False - unknown

Question 9

Biopsies are always diagnostic for GCA

Answer 9

False - segmental and skip lesions present

Question 10

A negative biopsy rules out GCA. True/false?

Answer 10

False

Question 11

Fibrinoid necrosis of vessel is buzzword for

Answer 11

Polyarthritis nodosa

Question 12

Wegner’s is a small/large vasculitis which is also known as….

Answer 12

Small vasculitis. AKA Granulomatosis with polyangiitis

Question 13

Churg-Strauss is AKA

Answer 13

Eosinophilic granulomatosis

Question 14

Most common cause of overproduction of gout

Answer 14

Idiopathic (Lysch-Nyham is rare)

Question 15

What is the most common cause of gout?

Answer 15

Under-excretion

Question 16

Urate secretion is reduced by which common cardiac / resp medication?

Answer 16

Thiazide diuretics

Question 17

Paget’s disease is a condition of more/less bone which is normal/abnormal.

Answer 17

More bone which is abnormal.

Question 18

RANK-L is associated with which condition?

Answer 18

Paget’s Disease

Question 19

Osteomalacia in the young is termed

Answer 19

Rickets

Question 20

Osgood-Schlatter’s affects which area and in which group?

Answer 20

Affects the patellar tendon at its tibial insertion, affects the sporty youth.

Question 21

Chondromalacia patella is AKA

Answer 21

Runner’s Knee

Question 22

GCA affects which artery?

Answer 22

Temporal arteries (may also involve ophthalmic and vertebral)

Question 23

Does a negative biopsy rule out GCA?

Answer 23

No, skip lesions

Question 24

Polyarteritis nodosa is a vasculitis of which vessel size?

Answer 24

Small to medium sized

Question 25

Does polyarteritis involve the lungs?

Answer 25

No, characteristically spares

Question 26

Polyarteritis nodosa typically affects which organ?

Answer 26

Kidney

Question 27

Is polyarteritis nodosa ANCA positive/negative?

Answer 27

Negative

Question 28

Which % of Polyarteritis Nodosa patients havee hepatitis B?

Answer 28

33%

Question 29

Henloch-Schlein-Purpura is a vasculitis of which vessel size?

Answer 29

Small

Question 30

Goodpasture's Syndrome is a vasculitis of which vessel size?

Answer 30

Small

Question 31

Are crystals from gout present after lab processing?

Answer 31

No, lost in formalin and residual amorphous eosinophilic debris

Question 32

Psuedogout is caused by what

Answer 32

Calcium pyrophosphate

Question 33

Psuedogout is often incidentally seen on which imaging modality?

Answer 33

X-ray

Question 34

What are the 3 stages of Paget's?

Answer 34

Osteolytic Mixed Burnt out

Question 35

"Thick excess bone with abnormal reversal line in a mosaic pattern" indicates which disease?

Answer 35

Paget's

Question 36

Leontiasis ossea is indicative of which disease?

Answer 36

Paget's (Lion's Face)

Question 37

Platybasia is indicative of which disease

Answer 37

Paget's (spine abnormality)

Question 38

Sabre tibia is indicative of which disease?

Answer 38

Paget's

Question 39

What's a potentially serious complication of Paget's Disease (cancer)?

Answer 39

Osteosarcoma

Question 40

"Rickety rosary" is a sign for which disease

Answer 40

Osteomalacia