pathology Flashcards

1
Q

how does hypoxic injury cause cellular swelling

A

reduced sodium pump activity causes isoosmotic gain of water

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2
Q

what is the cell type change called in barretts oesophagus

A

metaplasia

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3
Q

what is metaplasia

A

reversible change of one differentiated cell type to another

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4
Q

what usually causes metaplasia

A

chronic irritation or inflammation

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5
Q

what is dysplasia

A

abnormal cell growth and differentiation

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6
Q

what is atrophy

A

decreased size or number of cells

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7
Q

what is coagulative necrosis

A

cells retain shape and structure giving the tissue a firm texture

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8
Q

what is colliquative necrosis

A

tissue becomes liquified due to enzymatic breakdown of cells

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9
Q

what is autolysis

A

where tissue begins to rot / break itself down

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10
Q

name 2 ways in which neutrophils move

A

contracting cytoplasmic microtubules
chemotaxis

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11
Q

name the 3 steps of how we get neutrophils from blood to the tissue

A

margination
adhesion
emigration

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12
Q

what causes exudate

A

increased vascular permeability and increased net flow of fluid out of the vessels

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13
Q

exudate is primarily responsible for which cardinal sign of inflammation

A

swelling

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14
Q

what is the predominant inflammatory cell type in pus

A

neutrophil

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15
Q

which metastatic route involves tumour cells moving across a body cavity

A

transcoelomic

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16
Q

what is the most commonly mutated gene in human cancers

A

TP53

17
Q

what type of gene is TP53

A

tumour suppressor gene

18
Q

what are the 2 main functions of tumour suppressor genes

A

gatekeeping and caretaking