Pathology

Question 1

A 55-year-old man presents to her physician complaining of a 2 to 3month history of
cough. And occasionally blood with sputum. He is heavy smoker. Physical examination
reveals marked wheezing, and an x-ray of the chest demonstrates hilar lymph node
enlargement and a hilar mass on the right side. The mass is biopsied, and the histologic
specimen showed groups of uniform small oval cells with dark nucleus and scanty cytoplasm.
Which of the following is true for this tumor
(A) The tumor cells show keratin pearls
(B) Tumor cells show neurosecretory granules
(C) The sheet of tumor cells show peripheral palisading
(D)Glandular formation is characteristic

Answer 1

(B) Tumor cells show neurosecretory granules

Question 2

A 50-year-old woman visits her physician because of increasingly painful headaches. CT
of the head is showed an infiltrative irregular mass with central area of necrosis in left
cerebral hemisphere. The pathological sections showed highly cellular tumor with
pleomorphic cells and frequent mitosis. One of characteristic findings of this tumor
under microscope is………
(A) Monotonous cells with halos of cytoplasm surrounding rounded central nuclei
(B) Rosettes of tumor cells with oval nuclei
(C) Fascicles of tumor cells showing nuclear palisading alternating with nuclear-free
zones
(D) Palisading tumor cells surrounding foci of necrosis
(E) Whorled pattern of concentrically arranged spindle cells with psammoma bodies

Answer 2

(D) Palisading tumor cells surrounding foci of necrosis

Question 3

A 1.5-year-old boy complaining of fever, bone pains and bleeding from gum. Physical
examination reveals pallor, hepatomegaly, splenomegaly, and lymphadenopathy. He is
admitted to the hospital and undergoes bone marrow aspiration; results showed large
cells having scanty cytoplasm and large nucleus with one nucleolus. Which of the
following is the most likely diagnosis?
(A) Acute myeloblastic leukemia
(B) Acute lymphoblastic leukemia
(C) Ewing’s sarcoma
(D) Neuroblastoma
(E) Nephroblastoma

Answer 3

(B) Acute lymphoblastic leukemia

Question 4

A 30-year-old woman visits her physician with complaints of vaginal bleeding after
sexual intercourse. She acknowledges having unprotected sex with multiple partners.
Cytological smears are taken from the cervix. On microscopy, cervical cells showed high
N/C ratio, pleomorphic hyperchromatic nuclei with frequent mitotic figures. What would
most likely be present in the specimens that account for these findings?
(A) DNA virus
(B) Gram-negative diplococci
(C) Gram-positive cocci
(D) RNA virus
(E) Squamous cells covered with bacteria

Answer 4

(A) DNA virus