Pathology

Question 1

Pathergy Test-Disease, positive test?

Answer 1

Behcets Disease
within few days of pricking the skin with a sterile hypodermic needle–Papule/pustule/ulceration
no size requirements

Question 2

Type of HS reaction in Myasthenia/Graves?

Answer 2

Type V (subtype of Type II)

Question 3

Longest serum half life of which Ig?

Answer 3

GAMDE
IgG-21-23 days
IgA-6 days
IgM-5 days
IgD-3 days
IgE-2 days

Question 4

Which Ig readily crosses human placenta

Answer 4

IgG (actively and passively), small amounts of IgA (passively)

Question 5

Gene defect in Retinoblastoma

Answer 5

Rb gene on long arm of chromosome 13

Question 6

Pentameric Ig?

Answer 6

IgM

Question 7

Which Ig not detected in tear samples?

Answer 7

IgD
Primarily IgA found in tears

Question 8

Oldest Ig phylogenetically?

Answer 8

IgM

Question 9

First antibody produced against a newly encountered antigen ?

Answer 9

IgM
IgM peaks earlier and disappears earlier than IgG during the primary immune response.

Question 10

Most common oncogene in human tumours?

Answer 10

ras oncogene

Question 11

Mediators derived from plasma (and not cells)?

Answer 11

Complement,clotting factors,fibrinogen,kinin

Question 12

Which Ig may exist in polymeric form?

Answer 12

IgA-dimeric,IgM-pentameric

Question 13

IL 2 is produced by which cells?

Answer 13

Mainly by CD 4+ T cells

Question 14

Which Igs are important in responses to previously encountered antigens?

Answer 14

IgG,IgE

Question 15

Which immunoglobulin classes is/are important in antigen reception at the surface of lymphocytes in primary immune responses?

Answer 15

IgM,IgG,IgD can be demonstrated on the surface of virgin B-lymphocytes and are involved with initial binding of antigen in the primary response, leading to the activation of the cells.

Question 16

First cell that an antigen typically contacts in the cascade of immune response is?

Answer 16

Macrophage phagocytoses the antigen and presents it to T cells (APC)

Question 17

Most abundant Ig in serum?

Answer 17

IgG
(G>A>M>D>E)

Question 18

Which complement component is present in the highest serum concentrations?

Answer 18

C3

Question 19

SJS-type of HS reaction?

Answer 19

Type IV HS reaction, subtype C

Question 20

Wesley rings-type of HS reaction?

Answer 20

Type III
Wesley ring aka immune infiltrate occurs due to encounter of Stromal antigen with antibody from peripheral blood vessels.Contains complement factors and PMNs.

Question 21

Role of integrins?

Answer 21

Heterodimeric transmembrane protein- attaches cells to the extracellular matrix and to ligands on other cells
Has alpha and beta subunits
Requires Ca and Mg to function

Question 22

Most common site for ocular metastases?

Answer 22

Choroid
MC primaries- breast, prostate, lung, colon

Question 23

Mutations in receptors for TGF b leads to ?

Answer 23

Hereditary hemorrhagic telangiectasia