Pathology

Question 1

Langerhan’s histiocytosis

Answer 1

young kids
CD1a
punched out diaphyseal lesions
lesions in skull
recurrent ear pain

LCH subtypes:

1. Hand-Schuller- Christian- multiple bony and visceral lesions. Multiple skull lesions, diabetes insipidus, and exopthalmos
2. Eosinophilic granuloma- typically one single lesion
3. Letterer-Siwe- fatal in adolescence