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Boards > Drug MOA/ conditions used for > Flashcards

Drug MOA/ conditions used for Flashcards

1
Q

Denosumab

A

Monoclonal RANKL (competitive inhibitor) Ab GCT and osteoporosis

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2
Q

Etanarcept Inflixaimab Adalimumab

A

TNF a antagonist RA

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3
Q

Abatacept

A

MHC receptor antagonist RA

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4
Q

TXA

A

Synthetic lysine analog Competitively blocks plasmin activation from plasminogen

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5
Q

Fondaparinux

A

Indirect Factor Xa inhibitor

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6
Q

Dabigatran

A

Thrombin inhibitor

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7
Q

Heparin & lovenox

A

Activates Antithrombin 3 which then blocks factors X and Thrombin

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8
Q

Apixaban

A

Factor Xa inhibitor

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9
Q

Rivaroxaban

A

Direct Factor Xa inhibitor

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10
Q

Warfarin

A

Blocks Vit K reductase- blocking factors 2, 7, 9, 10 and proteins C&S

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11
Q

tPA & streptokinase

A

Increases plasmin which breaks down fibrin clots

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12
Q

Rituximab

A

CD20 (B cells) Monoclonal Ab Used w/ methotrexate for RA resistant to TNF-a blockers

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13
Q

TXA

A

Stabilizes fibrin clot by block plasminogen activation

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14
Q

Penicillin/ cephalosporins

A

beta- lactam

MOA- inhibits cell wall cross-linking

Resistance= beta- lactamase

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15
Q

Aminoglycosides (gentamycin, tobramycin)

A

Inhibit protein synthesis (30s subunit)

Used for G (-)/ polymicrobial infections

Side effects- hearing, renal toxicity and neuromuscular blockade

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16
Q

Macrolides (clinda, erythro, azithro, clarithro)

A

Inhibits dissociation of peptidyl-transfer RNA from ribosomes (binds 50s)

Clinda= bacteriostatic; G (+) & anaerobes; side effects- enterocolitis

17
Q

Tetracycline

A

Inhibit protein synthesis (binds 50s)

Stains teeth in kids (contraindicated < 8yo)

18
Q

Rifampin

A

Blocks RNA polymerase F

19
Q

Quinolones

A

Blocks DNA gyrase

Side effects- tendon rupture

20
Q

Oxazolidinones (linezolid)

A

Binds 50s to inhibit protein synthesis

21
Q

Botox

A

blocks ACh release by cleaves pre-synaptic SNAREs

Raynaud

Boards (10 decks)

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