Pathogenesis and Consequences of Venous THrombosis

Question 1

List the causation of Venous Thrombosis (Virchow’s Triad)

Answer 1

1. Stasis
2. Increased Coagulability
3. Damage to vein Wall

Question 2

Give examples of circumstances that may precipitate venous thrombosis

Answer 2

1. Surgery (knee/hip)
2. Malignancy
3. Pregnancy, Dehydration
4. ImmobilityInjury to body/limps/ fracture of bone
5. Hypercoagulable states, Acquired/ Congenital

Question 3

Describe the Acute Problems/ Consequences of Venous Thrombosis

Answer 3

Local
Calf Pain
Swelling of foot, leg, thigh if external Iliac and femoral veins are involved. In pregancy, severe forms of DVT give rise to cyanosis, pain and swelling.

Systemic
Pulmonary embolism. It is dangerous because if the main pulmonary arterie is occluded, then that could cause instant death.

Question 4

Describe the chronic problems/consequences of Venous Thrombosis.

Answer 4

Post-phletic syndrome
Venous insufficiency leads to venoud hypertension, leading to swollen leg, and diffuse fibrosis develops in subcutsneous fat leading to skin ulceration**
(lipodermasclerosis)**

venous insufficiency due to valve damage, occluded veins can cause Deep Vein Thrombosis

Raised Cappilary pressure can lead to Skin Ulceration

Chronic Pulmonary Emboli leads to sclerosis of pulmoanry arteries leading to pulmonary venous hypertension and eventual CARDIAC FAILURE.