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Microbiology > Pathogenesis > Flashcards

Pathogenesis Flashcards

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Biology 101 flashcards
1
Q

3 factors affecting pathogenesis

A

Pathogen
Host
Environment

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2
Q

Infective dose of Coxiella (Q fever)

A

1

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3
Q

Infective dose of shigella

A

10

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4
Q

Infective dose of Salmonella

A

100-1000

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5
Q

What is prodromal period?

A

When you feel disease coming

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6
Q

3 acute disease

A

Measles
Mumps
Flu

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7
Q

3 chronic diseases

A

TB
Leprosy
Syphilis

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8
Q

What is an example of a subacute disease?

A

Bacterial endocarditis

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9
Q

Is Gonorrhea symptomatic?

A

It’s symptomatic in males right away and in females months later

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10
Q

Is Trichomoniasis symptomatic?

A

It’s only symptomatic in females (which makes it hard to tract contact for males)

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11
Q

2 examples of latent diseases

A

Herpes & Chickenpox

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12
Q

How long does it take for syphilis tertiary phase?

A

5-50 years

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13
Q

How long does it take for syphilis secondary phase?

A

2-6 months

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14
Q

Virulence factors (3)

A

Integrin (receptor)
Adhesion (ligand)
Pili (fimbriae)

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15
Q

Adhesion & Receptor of GAS

A

Adhesion = Protein F
Receptor = fibronectin

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16
Q

Adhesion & Receptor of HIV

A

Adhesion: gp120
Receptor: CD4

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17
Q

What virulent factor is considered a colonization factor?

A

Fimbriae (pili)

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18
Q

Obligate intracellular pathogens

A

Chlamydia
Rickettsia
Ehrlichia
(Sporozoan protozoa;)
Plasmodium
Bebesia

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19
Q

2 Types of ehrlichia infections

A

Anaplasma (PMNL)
Ehrlichia (Monocyte)

20
Q

4 microbial mechanisms to escape host

A

Camouflage
Molecular mimicry
Antigenic variation
Destruction of antibodies

21
Q

Which microbe uses camouflage?

A

Schistosomes

22
Q

Which microbe uses molecular mimicry?

A

GAS > Hyaluronic acid capsule similar to humans
Mycoplasma pneumoniae > Makes cell fight own Ags

23
Q

Which microbe uses Antigenic variation?

A

Flu
HIV
Gonococcus
Borrelia
Trypanosomes (sleeping sick)

24
Q

Which microbe uses Destruction of Abs?

A

H. Flu
Gonococcus
Pneumococcus

25
Q

What does S. Aureus exoenzyme do ?

A

Coagulation

26
Q

Which bacteria use kinases?

A

Strep & Staph

27
Q

Which MOs produce Hyaluronidase exotoxin?

A

Strep , staph, Clostridium

28
Q

2 Necrotizing enzyme examples

A

Flesh eating GAS
Clostridium

29
Q

Which 2 MOs produce neurotoxins?

A

Clostridium tetani (tetanus)
Clostridium botulinum

30
Q

How does tetansospasmin work?

A

Inhibiting GABA release

31
Q

How does botulinal toxin work?

A

Block release of Ach

32
Q

Which MOs cause enterotoxin

A

Bacillus cereus
C. Difficile
Salmonella
C. Perfringens
Vibra cholerae
(to)
S. Aureus

33
Q

What does SSSS stand for

A

Staph Scalded skin syndrome

34
Q

What does STSS stand for?

A

Staph toxic shock syndrome

35
Q

Causes of STSS

A

Tampon
Nasal packing
Wounds

36
Q

What disease does GAS’s eythrogenic toxin cause?

A

Scarlet fever

37
Q

4 Potent exotoxins (sAg)

A

TSST-1
Enterotoxins (S. Aureus)
Enterotoxin (C. Perfringes)
Erythrogen toxin

38
Q

What is a superantigen?

A

Stimulates MHCII with very high potency and cause toxic shock

39
Q

What toxin causes septic shock?

A

G- endotoxin

40
Q

What toxin causes Toxic shock?

A

S. Aureus exotoxin

41
Q

4 exotoxins that inhibit protein synthesis?

A

C. Diphtheria
Pseudomonas aeruginosa
Shigella
E. Coli

42
Q

What toxin does E. Coli release?

A

Shiga like toxin

43
Q

Only pathogenic fungi (yeast) with a capsule?

A

Cryptococcus neoformans

44
Q

5 G+ bacteria with capsule?

A

Pneumococcus
S. Aureus/Epidermidis
Strep. Pyogenes/Agalactiae

45
Q

What kind of capsule does GBS (S. Agalactiae) have?

A

Sialic acid

46
Q

Bacteria with polypeptide capsule

A

Bacillus anthracis

Microbiology (16 decks)

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