Patho Unit 7 Flashcards
muscular tubes that carry urine to the bladder
ureters
external sphincter the controls urine outflow under voluntary control
urethra
functional unit of the excretory kidney
nephron
two types of nephrons
cortical
juxtamedullary
4 processes of the renal system
filtration
reabsorption
excretion
secretion
all substances found in the urine that are not reabsorbed back into the body (left in the filtrate)
excretion
accumulation of potassium, acids, fluid, and waste products that should have been removed in urine
anuria
results in fluid overload, acid-base disturbances, electrolyte abnormalities, and build up of waste products
renal failure (uremia)
in severe hypoglycemia, when the liver and kidneys make glucose from other substances
gluconeogenesis
filtrate flows down the ______ ______ in the cortex and reabsorption takes place here
proximal tubule
movement of fluids from filtrate back into the peritubular capillaries
reabsorption
things that are reabsorbed back into the peritubular capillaries
Na and Cl water amino acids glucose phosphate proteins
movement from peritubular capillaries back into the filtrate
secretion
a measure of renal glomular filtration
creatinine clearance
part of juxtamedullary nephron that creates a very salty environment in the medulla of the kidney
Loop of Henle
part of J nephron that monitors the filtrate to indirectly assess vascular volume
macula densa (dense body)
type of cells that release renin to activate the RAS
juxtaglomular apparatus
part of loop of Henle that prevents the rapid flow and washout of the concentration gradient
hairpin loop
once filtrate can no longer be changed by reabsorption or secretion, the filtrate is now called _____
urine
where is ADH synthesized
hypothalamus neurons
where is ADH stored
posterior pituitary gland
three reasons ADH would be released
elevated osmolarity
peripheral baroreceptor activation with hypotension
angiotensin 2 stimulation via RAS activity
mineralcorticoid hormone made by the adrenal gland that affects mineral homeostasis
aldosterone
disease caused by lowering production of aldosterone. involves Na wasting (hyponatremia) from excess loss of Na into the urine, K accumulation (hyperkalemia), and acidosis
Addison’s disease
disease caused by overproduction of aldosterone, Na and water retention (edema), K wasting (hypokalemia), and alkalosis
Cushing’s disease
two types of natriuretic peptides
brain (BNP) and atrial (ANP)
type of drug that interferes with the body’s sodium excretion resulting in increased sodium and water loading the increases overall blood volume and therefore blood pressure
NSAID’s
what is satisfied when our osmolality returns to normal and mouth dryness is relieved.
thirst response
stimulates salt eating
hyponatremia
metabolic waste product of muscle creatine that is filtered out in the urine
creatinine
amount of creatinine cleared out by filtration is a measure of
glomerular filtration rate
acute or chronic disease that can be caused by many things and deceases the GFR or tubular function
renal failure