patho of grave's disease

Question 1

what does the hypothalamus normally do?

Answer 1

• releases TRH to trigger ant pit to release TSH, which binds to TSH receptors on the thyroid gland
• stimulates T3 and T4 prod
• negative feedback occurs and hypothalamus and ant pit stop releasing TSH

Question 2

what is the difference in grave’s disease?

Answer 2

process stills occurs, but thyriod stimulating Abs are released as an autoimmune process

Question 3

what is the action of TsAbs?

Answer 3

same as TSH and result in a production of T3 and T4, which then inhibit TSH in negative feedback

Question 4

what do TsAbs continue to do when TSH is inhibited?

Answer 4

continue to be produced and bind to TSH receptors to continue prod of TH

Question 5

what does the continuous production and binding of TsAbs cause?

Answer 5

hyperfx and hypertrophyof the thyroid gland = overproduction of T3 and T4 and overstimulation of metabolism

Question 6

do TsAbs have competition for binding?

Answer 6

initially they compete for receptor sites with TSH, but as autoimmune disease progresses and TSH is suppressed, there’ no comp

Question 7

what does no competition for binding lead to?

Answer 7

abnormal thyroid stimulation

Question 8

what are TsAbs also known as?

Answer 8

thyroid stimulating immunoglobulins (TSI)