Hypothyroidism

Question 1

what are the types of hypothyroidism?

Answer 1

1) primary = thyroid –> 95% of hypothyroidism
2) secondary = pituitary
3) tertiary = hypothalamus

Question 2

what is the etiology of hypothyroidism?

Answer 2

• autoimmunity

- iatrogenic (radiation and Sx for hyperfx leads to hypofx)

Question 3

what is Hashimoto’s Thyroiditis?

Answer 3

most common hypothyroidism

Question 4

describe the patho of hasimoto’s?

Answer 4

1) autoimmunity targeting gland (Ab + T cells) –> inflmtn
2) Antithyroid Abs block TSH binding (prod dt autoimmunity)
3) lymphocyte infiltrates destroy gland (as they did in insulitis)
4) induce atrophy of gland and then fibrosis

Question 5

what gender is most affected?

Answer 5

90% are middle-aged women

Question 6

what are the mnftns of hashimotos?

Answer 6

1) hypometabolic state
2) myxedema
3) cold sensitivity
4) fatigued
5) decreased CO
6) decreased CNS fx
7) weak muscle action
8) increased weight

Question 7

myxedema

Answer 7

mucoid secretion in dermis of skin causing swelling and a waxy appearance

Question 8

why does cold sensitivity occur?

Answer 8

d/t less heat prod. normally is fixed in body by increased thyroid hormones, but is impaired

Question 9

why would you feel fatigued?

Answer 9

d/t less ATP prod

Question 10

why would you have decreased CO?

Answer 10

cardiac muscles do not have required ATP

Question 11

decreased CNS fx due to?

Answer 11

neurons require ATP for every AP

Question 12

weak muscle action will cause…

Answer 12

impaired breathing d/t resp muscle weakness

Question 13

why might you have increased weight?

Answer 13

• not metabolizing nutrients, putting it into storage
• ingest more CHO than metabolized = glucose converted to glycogen and stored in liver
• storage full = glucose stored as lipid elsewhere